Table 1 The baseline characteristics of large-cell neuroendocrine carcinoma patients
Surgery | Surgery (PSM) | ||||||
|---|---|---|---|---|---|---|---|
Variables | All n = 453 (%) | No n = 154 (%) | Yes n = 299 (%) | P-value | No n = 77 (%) | Yes n = 77 (%) | P-value |
Sex | 0.226 | 1.00 | |||||
Male | 238 (52.5) | 87 (56.5) | 151 (50.5) | 44 (57.1) | 44 (57.1) | ||
Female | 215 (47.5) | 67 (43.5) | 148 (49.5) | 33 (42.9) | 33 (42.9) | ||
Age (year) | 0.052 | 0.871 | |||||
≤ 65 | 220 (48.6) | 65 (42.2) | 155 (51.8) | 34 (44.2) | 35 (45.5) | ||
> 65 | 233 (51.4) | 89 (57.8) | 144 (48.2) | 43 (55.8) | 42 (54.5) | ||
Race | 0.019 | 0.841 | |||||
White | 363 (80.1) | 114 (74.0) | 249 (83.3) | 61 (79.2) | 62 (80.5) | ||
Other/ unknown | 90 (19.9) | 40 (26.0) | 50 (16.7) | 16 (20.8) | 15 (19.5) | ||
Marital status | 0.027 | < 0.001* | |||||
Unmarried | 211 (46.6) | 85 (55.2) | 218 (42.1) | 48 (62.3) | 23 (29.9) | ||
Married | 211 (48.8) | 62 (40.3) | 255 (53.2) | 26 (33.8) | 50 (64.9) | ||
Unknown | 21 (4.6) | 7 (4.5) | 20 (4.7) | 3 (3.9) | 4 (5.2) | ||
Location | < 0.001 | 0.297 | |||||
Upper | 302 (66.7) | 102 (66.2) | 200 (66.9) | 50 (64.9) | 49 (64.3) | ||
Lower | 114 (25.2) | 29 (18.8) | 85 (28.4) | 16 (20.8) | 22 (24.7) | ||
Other/ unknown | 37 (8.1) | 23 (15.0) | 29 (4.7) | 11 (14.3) | 17 (11.0) | ||
Laterality | 0.043* | 0.513 | |||||
Left | 199 (43.9) | 58 (37.7) | 141 (47.2) | 30 (39.0) | 34 (44.2) | ||
Right | 253 (55.8) | 95 (61.7) | 158 (52.8) | 47 (61.0) | 43 (55.8) | ||
Other/ unknown | 1 (0.3) | 1 (0.6) | 0 (0.0) | - | - | ||
T stage | < 0.001 | 0.668 | |||||
T1 | 186 (41.1) | 50 (32.5) | 136 (45.5) | 33 (42.9) | 28 (36.4) | ||
T2 | 145 (32.0) | 39 (25.3) | 106 (35.5) | 22 (28.6) | 26 (33.8) | ||
T3 | 47 (10.4) | 15 (9.7) | 32 (10.7) | 5 (6.5) | 8 (10.4) | ||
T4 | 75 (16.5) | 50 (32.5) | 25 (8.3) | 17 (22.0) | 15 (19.4) | ||
N stage | < 0.001 | 0.144 | |||||
N0 | 286 (63.1) | 67 (43.5) | 219 (73.2) | 44 (57.1) | 44 (57.1) | ||
N1 | 54 (11.9) | 7 (4.5) | 47 (15.7) | 5 (6.5) | 12 (15.6) | ||
N2 | 113 (25.0) | 80 (52.0) | 33 (11.1) | 28 (36.4) | 21 (27.3) | ||
Grade | < 0.001 | 0.211* | |||||
I─II | 11 (2.4) | 3 (1.9) | 8 (2.7) | 3 (3.8) | 2 (2.6) | ||
III | 231 (51.0) | 58 (37.7) | 173 (57.9) | 36 (46.8) | 29 (37.6) | ||
IV | 65 (14.3) | 67 (7.1) | 54 (18.1) | 5 (6.5) | 13 (16.9) | ||
Unknown | 146 (32.3) | 163 (53.3) | 64 (21.3) | 33 (42.9) | 33 (42.9) | ||
Radiotherapy | < 0.001 | 0.306* | |||||
No | 295 (65.1) | 45 (29.2) | 250 (83.6) | 35 (45.5) | 38 (49.4) | ||
Yes | 151 (33.3) | 106 (68.8) | 45 (15.1) | 41 (53.2) | 35 (45.5) | ||
Unknown | 7 (1.6) | 3 (2.0) | 4 (1.4) | 1 (1.3) | 4 (5.1) | ||
Chemotherapy | < 0.001 | 0.747 | |||||
No | 237 (52.3) | 55 (35.7) | 182 (60.9) | 38 (49.4) | 36 (46.8) | ||
Yes | 216 (47.7) | 99 (64.3) | 117 (39.1) | 39 (50.6) | 41 (53.2) | ||