Hemolysis and cardiopulmonary bypass: meta-analysis and systematic review of contributing factors

Table 4 Summary of findings of published studies comparing plasma free hemoglobin (PFHb) between different managements of suctioned blood

Suction blood management in cardiac surgery patients underwent CPB
Outcomes	№ of participants (studies) Follow-up	Certainty of the evidence (GRADE)	Relative effect (95% CI)	Anticipated absolute effects
Outcomes	№ of participants (studies) Follow-up	Certainty of the evidence (GRADE)	Relative effect (95% CI)	Risk with placebo	Risk difference with Suction Blood Management
Plasma Free Hemoglobin—Separated Reservoir	64 (3 RCTs)	⨁⨁◯◯ Low	–	The mean plasma Free Hemoglobin—Separated Reservoir was 0	MD 15.52 lower (28.29 lower to 2.75 lower)
Plasma Free Hemoglobin—Retransfusion	75 (2 RCTs)	⨁⨁⨁⨁ High	–	The mean plasma Free Hemoglobin—Retransfusion was 0	MD 14.69 lower (29.5 lower to 0.13 higher)

*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
CI confidence interval, MD mean difference
GRADE Working Group grades of evidence
High certainty: we are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect
Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect

ISSN: 1749-8090