Table 3 Effect of remote ischemic preconditioning on kidney function markers over time
From: Randomized controlled trial of remote ischemic preconditioning in children having cardiac surgery
N | Control | RPC | Difference | p value | |
|---|---|---|---|---|---|
Mean (95% CI) | Mean (95% CI) | (95% CI) | |||
Creatinine (mg/dL) | |||||
Baseline | 84 | 0.39 (0.33, 0.45) | 0.38 (0.33, 0.44) | − 0.006 (− 0.01, 0.080) | 0.898 |
6 h | 84 | 0.41 (0.35, 0.47) | 0.41 (0.35, 0.47) | 0.002 (− 0.083, 0.087) | 0.967 |
12 h | 83 | 0.44 (0.38, 0.50) | 0.46 (0.40, 0.51) | 0.015 (− 0.071, 0.100) | 0.735 |
24 h | 78 | 0.50 (0.44, 0.56) | 0.45 (0.39, 0.50) | − 0.056 (− 0.142, 0.031) | 0.188 |
48 h | 71 | 0.40 (0.34, 0.47) | 0.38 (0.32, 0.44) | − 0.021 (− 0.109, 0.067) | 0.638 |
72 h | 65 | 0.38 (0.32, 0.45) | 0.33 (0.27, 0.39) | − 0.052 (− 0.140, 0.036) | 0.247 |
Difference in slopes (95% CI)# | − 0.0007 (− 0.0015, 0.0002) | 0.109 | |||
Cystatin C (mg/L) | |||||
Baseline | 84 | 1.23 (1.10, 1.35) | 1.25 (1.13, 1.37) | 0.02 (− 0.15, 0.19) | 0.822 |
6 h | 84 | 0.95 (0.83, 1.08) | 1.01 (0.89, 1.12) | 0.05 (− 0.12, 0.22) | 0.547 |
12 h | 84 | 1.01 (0.88, 1.13) | 1.06 (0.95, 1.18) | 0.06 (− 0.12, 0.23) | 0.530 |
24 h | 78 | 1.14 (1.01, 1.27) | 1.16 (1.04, 1.27) | 0.02 (− 0.16, 0.19) | 0.862 |
48 h | 70 | 1.10 (0.97, 1.23) | 1.09 (0.97, 1.21) | − 0.005 (− 0.18, 0.17) | 0.959 |
72 h | 65 | 1.16 (1.03, 1.29) | 1.06 (0.94, 1.19) | − 0.10 (− 0.27, 0.08) | 0.300 |
Difference in slopes (95% CI)# | − 0.002 (− 0.003, − 0.0001) | 0.042 | |||
eGFR-Cr* (mL/min/1.73 m2) | |||||
Baseline | 84 | 108 (89, 126) | 102 (85, 120) | − 5 (− 31, 20) | 0.686 |
6 h | 84 | 89 (70, 107) | 89 (72, 106) | 0.2 (− 25, 26) | 0.986 |
12 h | 83 | 91 (73, 110) | 76 (58, 93) | − 15 (− 41, 10) | 0.234 |
24 h | 78 | 94 (75, 113) | 87 (70, 105) | − 7 (− 33, 19) | 0.612 |
48 h | 71 | 117 (98, 137) | 104 (86, 122) | − 14 (− 41, 13) | 0.300 |
72 h | 65 | 99 (79, 119) | 112 (93, 131) | 13 (− 14, 41) | 0.340 |
Difference in slopes (95% CI)# | 0.16 (− 0.16, 0.48) | 0.323 | |||
eGFR-CysC** (mL/min/1.73 m2) | |||||
Baseline | 84 | 65 (57, 73) | 66 (58, 74) | 0.9 (− 10, 12) | 0.873 |
6 h | 84 | 80 (72, 88) | 80 (72, 88) | 0.2 (− 11, 11) | 0.977 |
12 h | 84 | 79 (70, 87) | 77 (69, 84) | − 2 (− 13, 9) | 0.745 |
24 h | 78 | 70 (62, 78) | 73 (65, 80) | 3 (− 8, 14) | 0.628 |
48 h | 70 | 72 (63, 80) | 73 (65, 80) | 3 (− 10, 13) | 0.840 |
72 h | 65 | 68 (60, 77) | 74 (66, 82) | 5 (− 6, 17) | 0.360 |
Difference in slopes (95% CI)# | 0.07 (− 0.03, 0.16) | 0.157 |