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Table 2 Diagnosis and etiology for SAVR patients

From: Surgical aortic valve replacement etiologies, hemodynamics, and outcomes in 1346 patients from the Malaysian heart centre

Diagnosis subgroup

Diagnosis

Etiology

Variables

n (%) by total overall

Variables

n (%) by total diagnosis group

n (%) by total overall

Variables

n (%) by total diagnosis

n (%) by Total diagnosis group

AS Predominant

733 (54.5)

Severe AS

466 (63.6)

466 (34.6)

Bicuspid valve degeneration

211 (45.3)

211 (28.8)

Trileaflet valve degeneration

169 (36.3)

169 (23.1)

Rheumatic

57 (12.2)

57 (7.8)

Unknown

24 (5.2)

24 (3.3)

Unicuspid

4 (0.9)

4 (0.5)

Radiation

1 (0.2)

1 (0.1)

Total

466 (100.0)

 

Severe AS, Moderate AR

193 (26.3)

193 (14.3)

Rheumatic

67 (34.7)

67 (9.1)

Bicuspid valve degeneration

60 (31.1)

60 (8.2)

Trileaflet valve degeneration

55 (28.5)

55 (7.5)

Unknown

6 (3.1)

6 (0.8)

Radiation

2 (1.0)

2 (0.3)

Degenerative and fused prolapse

1 (0.5)

1 (0.1)

Fused prolapse

1 (0.5)

1 (0.1)

Bicuspid valve degeneration and flail fused leaflets

1 (0.5)

1 (0.1)

Total

193 (100.0)

 

Moderate AS

73 (10.0)

73 (5.4)

Bicuspid valve degeneration

29 (39.7)

29 (4.0)

Trileaflet valve degeneration

21 (28.8)

21 (2.9)

Rheumatic

19 (26.0)

19 (2.6)

Unicuspid

2 (2.7)

2 (0.3)

Unknown

1 (1.4)

1 (0.1)

Rheumatic and bicuspid valve degeneration

1 (1.4)

1 (0.1)

Mild AS

1 (0.1)

1 (0.1)

Bicuspid valve degeneration

1 (100.0)

1 (0.1)

Total

1 (100.0)

 

Total

733 (100.0)

 

Total

 

733 (100.0)

AR Predominant

497 (36.9)

Severe AR

343 (69.1)

343 (25.5)

Root dilatation

72 (21.0)

72 (14.5)

Infective endocarditis

57 (16.6)

57 (11.5)

Fused prolapse

42 (12.2)

42 (8.5)

Rheumatic

30 (8.7)

30 (6.0)

Prolapsed RCC

26 (7.6)

26 (5.2)

Unknown

18 (5.2)

18 (3.6)

Dissection

17 (5.0)

17 (3.4)

Prolapsed LCC

15 (4.4)

15 (3.0)

Bicuspid valve degeneration

7 (2.0)

7 (1.4)

SOV rupture

6 (1.7)

6 (1.2)

Trileaflet valve degeneration

6 (1.7)

6 (1.2)

Prolapsed NCC

6 (1.7)

6 (1.2)

Flail RCC

5 (1.5)

5 (1.0)

Flail fused

5 (1.5)

5 (1.0)

Flail NCC

3 (0.9)

3 (0.6)

Fused prolapse and root dilatation

3 (0.9)

3 (0.6)

Perforation RCC

2 (0.6)

2 (0.4)

Flail LCC

2 (0.6)

2 (0.4)

Quadricuspid

2 (0.6)

2 (0.4)

Prolapse of RCC into VSD

2 (0.6)

2 (0.4)

Prolapsed NCC and root dilatation

2 (0.6)

2 (0.4)

Destruction of LCC

1 (0.3)

1 (0.2)

Root dilatation and fused prolapse

1 (0.3)

1 (0.2)

Prolapsed LCC and root dilatation

1 (0.3)

1 (0.2)

Prolapsed RCC and root dilatation

1 (0.3)

1 (0.2)

Prolapsed NCC and RCC

1 (0.3)

1 (0.2)

Partial fusion with large coaptation defect

1 (0.3)

1 (0.2)

Retracted leaflets

1 (0.3)

1 (0.2)

Prolapsed RCC and idiopathic aortic dilatation

1 (0.3)

1 (0.2)

Post-myectomy complication

1 (0.3)

1 (0.2)

Prolapsed RCC and root dilatation

1 (0.3)

1 (0.2)

Root dilatation and prolapsed RCC

1 (0.3)

1 (0.2)

Fused prolapse, root dilatation and bicuspid valve degeneration

1 (0.3)

1 (0.2)

Flail NCC and root dilatation

1 (0.3)

1 (0.2)

Flail RCC and root dilatation

1 (0.3)

1 (0.2)

Retracted bicuspid

1 (0.3)

1 (0.2)

Total

343 (100.0)

 

Moderate AR

119 (23.9)

119 (8.8)

Rheumatic

31 (26.1)

31 (6.2)

Root dilatation

17 (14.3)

17 (3.4)

Prolapsed RCC

16 (13.4)

16 (3.2)

Trileaflet valve degeneration

16 (13.4)

16 (3.2)

Fused prolapse

8 (6.7)

8 (1.6)

Dissection

7 (5.9)

7 (1.4)

Unknown

5 (4.2)

5 (1.0)

Prolapsed LCC

4 (3.4)

4 (0.8)

Bicuspid valve degeneration

4 (3.4)

4 (0.8)

Infective endocarditis

3 (2.5)

3 (0.6)

Prolapsed NCC

3 (2.5)

3 (0.6)

Flail RCC

1 (0.8)

1 (0.2)

Trileaflet valve degeneration and root dilatation with intramural hematoma

1 (0.8)

1 (0.2)

Quadricuspid

1 (0.8)

1 (0.2)

Radiation

1 (0.8)

1 (0.2)

Degenerative due to subaortic membrane

1 (0.8)

1 (0.2)

Total

119 (100.0)

 

Moderate AS, Severe AR

34 (6.8)

34 (2.5)

Rheumatic

12 (35.3)

12 (2.4)

Fused prolapse

5 (14.7)

5 (1.0)

Infective endocarditis

4 (11.8)

4 (0.8)

Trileaflet valve degeneration

3 (8.8)

3 (0.6)

Bicuspid valve degeneration

3 (8.8)

3 (0.6)

Radiation

1 (2.9)

1 (0.6)

Root dilatation and trileaflet valve degeneration

1 (2.9)

1 (0.6)

Bicuspid valve degeneration and fused prolapse

1 (2.9)

1 (0.6)

Prolapsed NCC

1 (2.9)

1 (0.6)

Small LCC

1 (2.9)

1 (0.6)

Prolapsed RCC

1 (2.9)

1 (0.6)

Fused prolapse and annulus dilatation

1 (2.9)

1 (0.6)

Total

34 (100.0)

 

Mild AR

1 (0.2)

1 (0.1)

Rheumatic

1 (100.0)

 

Total

1 (100.0)

 

Total

497 (100.0)

 

Total

 

497 (100.0)

Similar severity

116 (8.6)

Severe AS and Severe AR

48 (41.4)

48 (3.6)

Bicuspid valve degeneration

15 (31.3)

15 (12.9)

Rheumatic

13 (27.1)

13 (11.2)

Trileaflet valve degeneration

9 (18.8)

9 (7.8)

Unknown

3 (6.3)

3 (2.6)

Trileaflet valve degeneration and prolapsed NCC

1 (2.1)

1 (0.9)

Bicuspid valve degeneration and fused prolapse

1 (2.1)

1 (0.9)

Iatrogenic AR and degenerative AS

1 (2.1)

1 (0.9)

Bicuspid valve degeneration and flail fused leaflets

1 (2.1)

1 (0.9)

Subaortic membrane

1 (2.1)

1 (0.9)

Flail fused and bicuspid valve degeneration

1 (2.1)

1 (0.9)

Flail RCC

1 (2.1)

1 (0.9)

Trileaflet valve degeneration and root dilatation

1 (2.1)

1 (0.9)

Total

48 (100.0)

 

Moderate AS and Moderate AR

68 (58.6)

68 (5.1)

Rheumatic

33 (48.5)

33 (28.4)

Trileaflet valve degeneration

17 (25.0)

17 (14.7)

Bicuspid valve degeneration

10 (14.7)

10 (8.6)

Radiation

1 (1.5)

1 (0.9)

Quadricuspid

1 (1.5)

1 (0.9)

Bicuspid valve degeneration and fused prolapse

1 (1.5)

1 (0.9)

Bicuspid valve degeneration and root dilatation

1 (1.5)

1 (0.9)

Unicuspid

1 (1.5)

1 (0.9)

Unknown

1 (1.5)

1 (0.9)

Fused prolapse

1 (1.5)

1 (0.9)

Prolapsed LCC

1 (1.5)

1 (0.9)

Total

68 (100.0)

 

Total

116 (100.0)

 

Total

 

116 (100.0)

Total

1346 (100.0)

  

1346 (100.0)

   
  1. Pure severe AS was the most common diagnosis, followed by pure severe AR. The most common etiology of pure severe AS was bicuspid valve degeneration, while that of pure AR was root dilatation. The most common diagnosis for AS predominant is bicuspid valve degeneration, and the most common diagnosis for AR predominant is root dilatation. Rheumatic is the most common diagnosis in the similar-severity group