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Table 3 Clinical outcomes

From: Surgical aortic valve replacement etiologies, hemodynamics, and outcomes in 1346 patients from the Malaysian heart centre

Inpatient stay

Length of inpatient stay (days)

Mean (SD)

11.7 (12.8)

Median (Q1, Q3)

8.0 (7.0, 12.0)

All-cause mortality rate

Variables

In-Hospital; n (%)

Follow-up; n (%)

Total 1-year; n (%)

1-month

6-month

1-year

N = 1346

N = 1128

N = 1033

N = 951

N = 1037

Overall

Total mortality

86 (6.4)

29 (2.6)

49 (4.7)

67 (7.0)

153 (14.8)

AVR Group

Isolated AVR mortality

38 (5.6)

15 (2.6)

25 (4.7)

35 (7.3)

73 (14.1)

Non-isolated AVR

48 (7.2)

14 (2.6)

24 (4.8)

32 (6.8)

80 (15.4)

Diagnosis

Severe AS

38 (8.2)

10 (2.6)

18 (5.0)

26 (8.0)

64 (17.6)

Severe AR

20 (5.8)

9 (3.1)

12 (4.4)

15 (5.9)

35 (12.7)

Moderate AS

5 (6.8)

1 (1.6)

4 (6.8)

5 (9.4)

10 (17.2)

Moderate AR

4 (3.4)

1 (1.0)

4 (4.4)

5 (6.0)

9 (10.3)

Severe AS and Severe AR

2 (4.2)

1 (2.4)

1 (2.7)

2 (5.4)

4 (10.3)

Moderate AS and Moderate AR

3 (4.4)

0

1 (2.3)

1 (2.6)

4 (9.8)

Severe AS, Moderate AR

13 (6.7)

6 (3.8)

7 (4.8)

11 (8.3)

24 (16.4)

Moderate AS, Severe AR

1 (2.9)

1 (3.4)

2 (7.7)

2 (8.0)

3 (11.5)

Mild AS

0

0

0

0

0

Mild AR

0

0

0

0

0

AS-Predominant vs. AR-Predominant vs. Similar-Severity Group

AS Predominant

56 (7.6)

17 (2.8)

29 (5.1)

42 (8.2)

98 (17.2)

AR Predominant

25 (5.0)

11 (2.6)

18 (4.7)

22 (6.1)

47 (12.1)

Similar Severity

5 (4.3)

1 (1.1)

2 (2.5)

3 (4.0)

8 (10.0)

AS-Predominant by Etiology

Bicuspid valve degeneration

14 (4.7)

3 (1.1)

5 (2.0)

6 (2.7)

20 (8.5)

Trileaflet valve degeneration

33 (13.5)

7 (3.5)

15 (8.1)

23 (13.4)

56 (27.3)

Rheumatic

6 (4.2)

4 (3.6)

6 (6.0)

9 (10.1)

15 (15.8)

Unicuspid

0

0

0

0

0

Radiation

0

0

0

0

0

Others

3 (8.6)

3 (10.0)

3 (10.7)

4 (16.0)

7 (25.0)

AR-Predominant by Etiology

Root dilatation

5 (5.6)

2 (2.6)

5 (7.4)

5 (7.8)

10 (14.5)

Rheumatic

1 (1.4)

0

2 (3.8)

2 (3.9)

3 (5.8)

Infective endocarditis

7 (10.9)

2 (4.2)

2 (4.7)

3 (7.1)

10 (20.4)

Fused prolapse

1 (1.8)

1 (2.1)

1 (2.2)

1 (2.6)

2 (5.0)

Prolapsed RCC

2 (4.7)

0

2 (5.3)

3 (8.3)

5 (13.2)

Trileaflet valve degeneration

2 (8.0)

1 (4.5)

1 (5.3)

2 (11.1)

4 (20.0)

Dissection

3 (12.5)

1 (5.0)

1 (5.9)

2 (11.8)

5 (25.0)

Prolapsed LCC

1 (5.3)

2 (11.8)

2 (11.8)

2 (12.5)

3 (17.6)

Bicuspid valve degeneration

0

0

0

0

0

Prolapsed NCC

0

0

0

0

0

Flail RCC

1 (16.7)

0

0

0

1 (33.3)

SOV rupture

0

0

0

0

0

Flail fused

0

0

0

0

0

Flail NCC

1 (33.3)

0

0

0

1 (33.3)

Quadricuspid

0

0

0

0

0

Fused prolapse and root dilatation

0

0

0

0

0

Others

1 (1.9)

2 (4.4)

2 (4.7)

2 (5.0)

3 (7.3)

Similar-Severity by Etiology

Rheumatic

1 (2.2)

1 (2.9)

1 (3.3)

2 (8.0)

3 (11.5)

Trileaflet valve degeneration

2 (7.7)

0

0

0

2 (10.0)

Bicuspid valve degeneration

1 (4.0)

0

0

0

1 (5.9)

Others

1 (5.3)

0

1 (6.3)

1 (6.3)

2 (11.8)

AS Hemodynamic

HG-severe AS

29 (6.0)

11 (2.7)

14 (3.8)

23 (6.8)

52 (14.2)

PLF-LG severe AS

7 (11.3)

1 (2.0)

3 (6.3)

5 (11.6)

12 (24.0)

NF-LG severe AS

8 (8.2)

2 (2.4)

4 (4.9)

6 (7.9)

14 (16.7)

LF-LG severe AS

8 (13.6)

3 (6.7)

5 (11.9)

5 (13.5)

13 (28.9)

Moderate AS

8 (5.2)

2 (1.6)

6 (5.2)

7 (6.6)

15 (13.2)

Mild AS

6 (6.7)

1 (1.4)

2 (3.2)

2 (3.5)

8 (12.7)

Reverse area-gradient mismatch (moderate AS)

1 (3.8)

0

1 (5.3)

1 (6.7)

2 (12.5)

  1. The overall in-hospital and total 1-year mortality rates were 6.4% and 14.8%, respectively. Pure severe AS has the highest in-hospital and total 1-year mortality. Bicuspid valve degeneration has had the best survival at 1 year for AS-predominant etiology, followed by rheumatic, and the worst is trileaflet valve degeneration. Dissection and IE have the worst outcome for AR predominant subgroup. Hemodynamically for AS, the poorest outcome occurs in LF-LG severe AS
  2. In-hospital” indicates those patients who died in-hospital before discharge
  3. Follow-up” indicates those patients who were alive at discharge but died at 1-month, 6-months and 1-year follow-up
  4. Total 1-year” indicates total number of patients who are dead at 1-year including in-hospital deaths