Continuous variables | |||||
---|---|---|---|---|---|
Variable | Number of studies | MD [95% CI] for DWPOD1 | P-value | GRADE certainty of evidence | |
Preoperative Characteristics | Age | 7 | − 1.65 [− 2.56, − 0.75] |  < 0.001 | Low |
BMI (kg/m2) | 4 | 0.44 [0.12, 0.75] | 0.007 | High | |
DLCO (% of Predicted) | 4 | 4.91 [1.73, 8.09] | 0.002 | Moderate | |
FEV1 (% of Predicted) | 4 | 4.72 [1.58, 7.85] | 0.003 | Low | |
Operative Characteristics | Operation Duration (Minutes) | 4 | − 28.08 [− 41.65, − 14.51] |  < 0.001 | Very Low |
Categorical variables | |||||
---|---|---|---|---|---|
Variable | Number of studies | RR/OR [95% CI] for DWPOD1 | P-value | GRADE certainty of evidence | |
Preoperative Characteristics | Upper Lobe Pathology (vs. Lower/Middle Lobe) | 4 | 1.04 [0.93, 1.16] | 0.12 | Low |
Smokers | 4 | 0.68 [0.61, 0.76] |  < 0.001 | High | |
White/Caucasian Race (vs. All Other Races) | 4 | 1.02 [0.84, 1.24] | 0.86 | Moderate | |
Preoperative Steroids | 4 | 0.91 [0.62, 1.34] | 0.63 | Moderate | |
PVD | 4 | 0.72 [0.56, 0.91] | 0.007 | Moderate | |
Malignant (vs. Benign) Lung Pathology | 5 | 0.68 [0.56, 0.82] |  < 0.001 | High | |
HTN | 6 | 0.82 [0.73, 0.93] | 0.001 | Moderate | |
Diabetes | 5 | 0.96 [0.79, 1.16] | 0.65 | Moderate | |
CAD | 5 | 0.72 [0.69, 0.76] | < 0.001 | High | |
COPD | 6 | 0.70 [0.58, 0.84] |  < 0.001 | Moderate | |
CHF | 5 | 0.74 [0.67, 0.81] |  < 0.001 | High | |
Male Sex (vs. Female Sex) | 7 | 1.03 [0.91, 1.17] | 0.60 | Low | |
ASA Score < 3 (vs. ASA Score ≥ 3) | 4 | 2.29 [0.67, 7.82] | 0.18 | Very Low | |
Operative Characteristics | Minimally Invasive Approach (vs. Open Approach) | 7 | 6.17 [1.91, 19.93] | 0.002 | Moderate |
Lobar Resection (vs. Sublobar Resection) | 4 | 0.35 [0.24, 0.51] |  < 0.001 | High | |
Postoperative Characteristics | Postoperative 30-Day Readmission | 7 | 0.84 [0.62, 1.14] | 0.27 | Low |
Postoperative 30-Day Mortality | 7 | 1.01 [0.50, 2.05] | 0.97 | Low | |
Major Morbidity | 3 | 0.31 [0.24, 0.41] |  < 0.001 | High | |
Discharged With Chest Tube | 3 | 0.38 [0.15, 0.91] | 0.03 | Moderate | |
Air Leak (> 5 Days) | 2 | 0.19 [0.08, 0.46] |  < 0.001 | High |