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Table 1 Clinical characteristics of ILD patients who have undergone pulmonary resection

From: Surgical outcomes and perioperative risk factors of patients with interstitial lung disease after pulmonary resection

 

Whole group

N = 78 (%)

Non-POC group

N = 58 (%)

POC group

N = 20 (%)

P valuea

Gender

    

 Male

64 (82.1)

47 (81)

17 (85)

0.690

 Female

14 (17.9)

11 (19)

3 (15)

Age(year), Median (range)

66.5 (33–86)

66 (33–80)

73 (57–86)

0.001b

Smoking history

    

 Current smoker

24 (30.8)

20 (34.5)

4 (20)

0.196

 Ex-smoker

20 (25.6)

12 (20.7)

8 (40)

 Non-smoker

34 (43.6)

26 (44.8)

8 (40)

 Smoking index of smokers (package-years), Median (range)

40 (10–150)

40 (10–120)

50 (20–150)

0.507b

Comorbidity

    

 COPD

14 (17.9)

7 (12.1)

7 (35)

0.049

 Coronary heart disease

20 (25.6)

12 (20.7)

8 (40)

0.088

 Autoimmune disease

10 (12.8)

8 (13.8)

2 (10)

0.960

Environmental exposures

10 (12.8)

9 (15.5)

1 (5)

0.409

Type of ILD

    

 IPF

40 (51.3)

26 (44.8)

14 (70)

0.183

 iNSIP

23 (29.5)

20 (34.5)

3 (15)

 CTD-ILD

11 (14.1)

8 (13.8)

3 (15)

 Other types

4 (5.1)

4 (6.9)

0 (0)

Scope of ILD on CT imaging

    

 Localized distribution

61 (78.2)

45 (77.6)

16 (80)

1.000

 Diffuse distribution

17 (21.8)

13 (22.4)

4 (20)

Preoperative condition of ILD

    

 Stable

64 (82.1)

49 (84.5)

15 (75)

0.539

 Unstable or aggravated

14 (17.9)

9 (15.5)

5 (25)

Preoperative PFT, Mean±SD (range)

    

 FEV1 (% pred)

77.98±16.28

78.43±16.29

76.76±16.61

0.698

 FVC (% pred)

79.32±18.01

78.34±18.65

81.97±16.31

0.446

 FEV1/FVC (% pred)

76.21±11.04

77.71±10.46

72.16±11.82

0.054

 MVV (% pred)

72.09±16.96

70.45±15.33

76.46±20.47

0.179

 DLCO (% pred)

66.22±17.99

67.46±19.03

62.88±14.72

0.334

Preoperative ABG, Mean±SD

    

 PaO2 (mmHg)

78.95±8.99

78.45±9.37

80.42±7.79

0.412

 PaCO2 (mmHg)

38.72±3.42

39.02±3.34

37.84±3.61

0.198

 SaO2 (%)

95.66±1.95

95.62±1.99

95.79±1.84

0.745

Location of Primary lung cancer

    

 Right upper lobe

16 (32)

8 (24.2)

8 (47.1)

0.292c

 Right middle lobe

4 (8)

4 (12.1)

0 (0)

 Right lower lobe

9 (18)

5 (15.2)

4 (23.5)

 Left upper lobe

11 (22)

8 (24.2)

3 (17.6)

 Left lower lobe

10 (20)

8 (24.2)

2 (11.8)

Pathology of pulmonary lesion

    

 Benign lesion or ILD

28 (35.9)

25 (43.1)

3 (15)

0.024

 Primary lung cancer

50 (64.1)

33 (56.9)

17 (85)

  Adenocarcinoma

21 (42)

15 (45.5)

6 (35.3)

0.405

  Squamous carcinoma

16 (32)

10 (30.3)

6 (35.3)

  Large cell neuroendocrine carcinoma

2 (4)

2 (6.1)

0 (0)

  Small cell carcinoma

8 (16)

3 (9.1)

5 (29.4)

   Small cell carcinoma mixed squamous cell carcinoma

1 (2)

1 (3.0)

0 (0)

   Other types

2 (4)

2 (6.1)

0 (0)

Pathological TNM stage

    

 I

29 (58)

18 (54.5)

11 (64.7)

0.842c

 II

6 (12)

5 (15.2)

1 (5.9)

 III

10 (20)

7 (21.2)

3 (17.6)

 IV

5 (10)

3 (9.1)

2 (11.8)

  1. Statistical method: a: Pearson’s χ2 test; b: Mann-Whitney U test; c: Fisher exact test;
  2. Abbreviation: ABG: arterial blood gas; COPD: chronic obstructive pulmonary disease; CTD-ILD: connective tissue diseases related interstitial lung disease; DLCO: diffusing capacity of carbon monoxide; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; iNSIP: idiopathic nonspecific interstitial pneumonia; ILD: interstitial lung disease; IPF: idiopathic pulmonary fibrosis; MVV: maximal voluntary ventilation; PaO2: arterial oxygen pressure; PaCO2: arterial carbon dioxide pressure; PFT: pulmonary function test; POC: postoperative 90-day complications; SaO2: arterial oxygen saturation; SD: standard deviation;
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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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