Similar survival after endoscopic submucosal dissection and esophagectomy in early esophageal cancer and synchronous or metachronous head and neck cancer

Table 4 Results of univariate analysis for overall and relapse-free survivals in 106 patients with 8th AJCC pathologic stage I esophageal squamous cell carcinoma

Factors	No. of patients	OS		RFS
Factors	No. of patients	3-year OS (%)	p	3-year RFS (%)	p
Age
< 55 years	55	77%	0.075	74%	0.0291*
≥ 55 years	51	74%		64%
Clinical 8th AJCC stage
0	10	100%	0.0028*	90%	0.0062*
I	80	75%		70%
II	14	50%		43%
III	2	100%		100%
Clinical T stage
Tis	11	100%	0.0055*	91%	0.0125*
T1a	79	76%		70%
T1b	16	56%		50%
Clinical N stage
N0	97	75%	0.47	70%	0.49
N1	7	71%		57%
N2	2	100%		100%
Tumor grade
Grade 0 (Tis)	13	92%	0.486	92%	0.05*
Grade 1	8	63%		63%
Grade 2	78	75%		66%
Grade 3	7	86%		86%
Primary tumor location
Upper	21	76%	0.0343*	71%	0.075
Middle	53	65%		60%
Lower	32	91%		84%
Pathologic 8th AJCC stage
0 (Tis)	17	94%	0.198	94%	0.249
IA	3	67%		67%
IB	86	72%		65%
Pathologic 8th AJCC T stage
0	17	94%	0.193	94	0.25
T1a	34	78%		69
T1b	55	68%		63
R0 resection
Yes	99	75%	0.438	69%	0.754*
No	7	83%		86%
Procedure
Endoscopic submucosal dissection	25	87%	0.118	83%	0.085
Esophagectomy	81	72%		66%
Synchronous H&N cancer
No	53	82%	0.593	77%	0.494
Yes	53	69%		63%
Metachronous H&N cancer
No	87	73%	0.471	68%	0.605
Yes	19	79%		74%

*Statistically significant
OS, overall survival; RFS, relapse-free survival; AJCC, Americal Joint Committee on Cancer; H&N, head and neck

ISSN: 1749-8090