Fig. 2
The activated Nrf2/HO-1 pathway relieved the lung injury and inflammatory response in COPD mice. A Western blot of lung tissues indicated the inactivated Nrf2/HO-1 pathway by ML385 treatment and activated Nrf2/HO-1 pathway by DMF intervention in COPD mice. B H&E staining of the lung tissues suggested the relieved lung injury and inflammatory infiltration by activating the Nrf2/HO-1 pathway in COPD mice. C Lung function test revealed the reduced airway resistance by activating the Nrf2/HO-1 pathway in COPD mice. D ELISA of the alveolar lavage fluid revealed the decreased proinflammatory factors (IL-1β and IL-6) by activating the Nrf2/HO-1 pathway in COPD mice. **P < 0.01 and ***P < 0.001 vs. Control group. ## P < 0.01 and ### P < 0.001 vs. COPD group