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Fig. 6 | Journal of Cardiothoracic Surgery

Fig. 6

From: METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes

Fig. 6

Role and mechanism of METTL14 in regulating H/R-induced ferroptosis in cardiomyocytes. METTL14 induces the recognition and processing of pri-miR-146a-5p by DGCR8 by up-regulating the m6A methylation level on pri-miR-146a-5p, which promotes the expression of miR-146a-5p, which in turn targets and represses the transcriptional level of APPL1 and promotes H/R-induced ferroptosis in cardiomyocytes

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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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