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Volume 10 Supplement 1

Proceedings of the WSCTS 25th Anniversary Congress

  • Meeting abstract
  • Open Access

Tumor volume is an independent predictor of survival in patients with malignant pleural mesothelioma

  • 1,
  • 2,
  • 3,
  • 4,
  • 5 and
  • 1
Journal of Cardiothoracic Surgery201510 (Suppl 1) :A48

https://doi.org/10.1186/1749-8090-10-S1-A48

©  Kircheva et al. 2015

  • Published:

Keywords

  • Independent Predictor
  • Tumor Volume
  • Tumor Burden
  • Resected Specimen
  • Pathological Stage

Background/Introduction

Tumor histology and stage are predictors of survival in patients with malignant pleural mesothelioma (MPM). The TNM classification that is widely accepted for MPM has its limitations. Significance of tumor volume, a better representation of tumor burden is not routinely determined. We hypothesized tumor volume is a better predictor of survival and complimentary to T and N stage. Extended pleurectomy and decortication (EPD), a lung sparing procedure, provides an opportunity to measure the tumor volume and pathological stage.

Aims/Objectives

Evaluate the significance of tumor volume on overall survival in patients undergoing EPD for MPM.

Method

111 patients who underwent EPD for MPM formed the basis of this report. The following variables were assessed: age, gender, histology including percent epithelioid histology and pathological T and N stage. Tumor volume of resected specimens was measured using a water displacement method. A Cox regression model was used to identify significant predictors of survival. Kaplan-Meier was used to summarize overall and subgroup survival.

Results

There were 91 males and 20 females with a median age of 68 years (range 43-88 years). Median tumor volume was 560 ml (range 100-2200 ml). Tumor volume was less than 300 ml in 18 patients, between 301-600cc in 37 patients, 601-900 in 29 patients and >900cc in 25 patients. Five patients (4.5%) died within 30 days of surgery. Overall two year survival from diagnosis was 48.3% and from EPD was 31.5%. Tumor volume was a significant predictors of survival (p = 0.001, Table 1) and T stage (p = 0.05). No relationship between N stage and either tumor volume or histology was observed.

Table 1

Volume

Median survival

<300 ml

2.25 years

301-600 ml

1.62 years

601-900 ml

1.06 years

> 900 ml

0.9 years

Discussion/Conclusion

Tumor volume is an independent predictor of survival in patients with MPM undergoing EPD.

Tumor volume is an important measure and is complimentary to TNM staging

Authors’ Affiliations

(1)
Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA
(2)
Department of Pathology, University of Chicago Medicine, Chicago, IL 60637, USA
(3)
Department of Biostatistics, University of Chicago Medicine, Chicago, IL 60637, USA
(4)
Department of Radiology, University of Chicago Medicine, Chicago, IL 60637, USA
(5)
Department of Medicine, University of Chicago Medicine, Chicago, IL 60637, USA

Copyright

© Kircheva et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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