- Meeting abstract
- Open Access
Tumor volume is an independent predictor of survival in patients with malignant pleural mesothelioma
© Kircheva et al. 2015
- Published: 16 December 2015
- Independent Predictor
- Tumor Volume
- Tumor Burden
- Resected Specimen
- Pathological Stage
Tumor histology and stage are predictors of survival in patients with malignant pleural mesothelioma (MPM). The TNM classification that is widely accepted for MPM has its limitations. Significance of tumor volume, a better representation of tumor burden is not routinely determined. We hypothesized tumor volume is a better predictor of survival and complimentary to T and N stage. Extended pleurectomy and decortication (EPD), a lung sparing procedure, provides an opportunity to measure the tumor volume and pathological stage.
Evaluate the significance of tumor volume on overall survival in patients undergoing EPD for MPM.
111 patients who underwent EPD for MPM formed the basis of this report. The following variables were assessed: age, gender, histology including percent epithelioid histology and pathological T and N stage. Tumor volume of resected specimens was measured using a water displacement method. A Cox regression model was used to identify significant predictors of survival. Kaplan-Meier was used to summarize overall and subgroup survival.
> 900 ml
Tumor volume is an independent predictor of survival in patients with MPM undergoing EPD.
Tumor volume is an important measure and is complimentary to TNM staging
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