- Case report
- Open Access
- Open Peer Review
A successfully thrombolysed acute inferior myocardial infarction due to type A aortic dissection with lethal consequences: the importance of early cardiac echocardiography
© Tsigkas et al; licensee BioMed Central Ltd. 2011
- Received: 27 March 2011
- Accepted: 24 August 2011
- Published: 24 August 2011
Thrombolysis, a standard therapy for ST elevation myocardial infarction (STEMI) in non-PCI-capable hospitals, may be catastrophic for patients with aortic dissection leading to further expansion, rupture and uncontrolled bleeding. Stanford type A aortic dissection, rarely may mimic myocardial infarction. We report a case of a patient with an inferior STEMI thrombolysed with tenecteplase and followed by clinical and electrocardiographic evidence of successful reperfusion, which was found later to be a lethal acute aortic dissection. Prognostic implications of early diagnosis applying transthoracic echocardiography (TTE) are described.
- Acute Myocardial Infarction
- Aortic Dissection
- False Lumen
- Acute Aortic Dissection
Acute myocardial infarction (AMI) usually results from an occlusive coronary thrombus at the site of a ruptured atherosclerotic plaque . Reperfusion therapies such as primary percutaneous coronary intervention (PPCI) and thrombolysis are mandatory steps for reducing mortality and limiting the infarct size in patients with ST segment elevation myocardial infarction (STEMI). The greatest benefit occurs, if reperfusion therapy is initiated within the first hours from the onset of symptoms and there is no preference for either strategy, if these symptoms are present for less than 3 hours . Clinically speaking, many conditions, such as acute aortic dissection, pericarditis, pulmonary embolism and myocarditis may mimic acute myocardial infarction. Thrombolysis in most of these situations is absolutely contraindicated due to its potentially lethal complications. Clinicians should always bear in mind the possibility that a type A aortic dissection (AAD) may mimic an AMI, which requires an urgent surgical repair without any delay.
Thrombolysis is currently recommended for patients with STEMI presenting in non-PCI-capable centers, especially when PCI in less than 2 h transfer is not possible . Patients with similar symptoms, but without myocardial infarction, may be falsely treated with thrombolysis. Acute ascending aortic dissection associated with AMI is rare, with a reported incidence of 1 to 2% . In previous reports [5, 6], most patients with aortic dissection, who were treated with thrombolytic agents died due to hemorrhagic complications. The non-invasive identification of successful fibrinolysis remains a challenging issue, using pain cessation and more than 50 per cent ST-segment resolution in the lead(s) with the highest ST-segment elevations 60 to 90 minutes after initiation of fibrinolytic therapy as a useful surrogate . Although, the primary event, which caused AMI was aortic dissection, two hypotheses may explain the coronary occlusion. Since the dissection can partially occlude the ostium of a coronary artery, it can modify the blood flow and pressure inside the vessel, leading to coronary thrombosis and consequent myocardial infarction. Tenekteplase, by dissolving the thrombi through the false lumen of the coronary artery and aortic root, allowed reperfusion, but later led to further bleeding and occlusion . Another possibility is that a coronary spasm was the cause of the STEMI, due to nearby hematoma or pressure of the false lumen which resolved with the use of the adjuvant therapy, such as nitrates. The followed inappropriate thrombolysis probably affected adversely the outcome by being the causative factor for the further expansion of the tear and by causing difficulties with the hemostasis at the surgery [8, 9]. Aortic dissection is caused by an intimal tear following elastic degeneration, smooth muscle cells loss or elevated pressure in vasa vasorum, which leads to rupture and allows the creation of a false lumen between the media and adventitia . The presence of severe chest pain of very sudden onset, usually described as tearing and followed from a feeling of impending death, a discrepancy in the pulse or blood pressure in the two upper extremities or between upper and lower extremities and a widening of mediastinal on chest X-ray are reported to have a probability of 96% for the diagnosis of AAD. On the other hand, if those signs are not present, the probability of AAD is only 7% . Sometimes is difficult to distinguish AAD from angina pectoris. Other common presentations for type A dissections include syncope (13% of type A AADs) and abdominal pain (22% of type A AADs and 43% of type B AADs). The above symptoms have important prognostic implications, signaling increased risks for shock, ischemia or infarction complications of mesenteric and limb arteries and in-hospital mortality, mainly because of delay in diagnosis . Most of the patients with AAD, about 75%, have a history of hypertension . Aortic dissection is less common than myocardial infarction and its association with ST segment elevation is unusual [14, 15]. This combination can be recognized early with the help of diagnostic imaging, minimizing the risk of thrombolysis in selected patients. Bedside chest X-ray is not sufficient to rule out aortic dissection, but a great percentage of patients with AAD have an abnormal one, often showing a distended aorta or generalized widening of the mediastinum . Transthoracic followed by transesophageal echocardiography (TEE), MDCTA and Magnetic Resonance Imaging (MRI) are very important and essential imaging tools with high sensitivity and specificity for early life-saving diagnosis of aortic dissection . The TTE is of great importance because it is an easy, non-invasive, widely available and minimally time consuming technique, which can play a major role in differential diagnosis in emergency department. It can provide much information about possible aortic dilation and insufficiency of the aortic valve, pericardial and/or pleural effusion and finally about a dissection flap, which is the hallmark for the diagnosis of the aortic dissection. Despite that a remarkable improvement in development of new biomarkers has been made, there is no widely accepted strategy in this field. The biochemical diagnosis of aortic dissection has become possible by identifying raised concentrations of smooth muscle myosin heavy chain . More recently, widely available biomarkers, such as D-dimer are thought to play an assistive role . Our knowledge for the identification and the management of acute aortic pathology has made a tremendously improvement, mainly due to International Registry of Acute Aortic Dissection (IRAD). It is now known that if type A AAD remains untreated, one third of patients die within the first 24 hours, and the half of them die within 48 hours. According to latest data, surgery is the best option with a mortality rate of 5 to 21% for type A AAD and medication only is the best choice for an uncomplicated type B AAD with a mortality rate of approximately 20% .
Thrombolytic treatment for STEMI, whenever PCI is not available, should not be postponed, except in cases of suspected aortic dissection. Our case shows that even clinical and electrocardiographic signs of successful reperfusion can occur when aortic dissection is the primary cause of the myocardial infarction. The presence of eccentric aortic regurgitation, the dilated ascending aorta and the possible visualization of double lumen by TTE could provide strong hints of the coexistence of AMI and type A aortic dissection. In conclusion, if aortic dissection is suspected, arrangement of the appropriate imaging studies should be done without further delay. Hence, bedside TTE can help as it is an easy, safe and rapid procedure to diagnose proximal aortic dissection without crucial delay. Cardiologists should bear in mind this usually lethal complication of acute aortic dissection and perform TTE prior to catheterization and even more before fibrinolysis.
Written informed consent was obtained from the next of kin of the deceased patient for publication of this case report and the accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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