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Fulminant myocarditis managed with pulsatile extracorporeal life support; use of Twin Pulse Life support (T-PLS®)
© Cho et al; licensee BioMed Central Ltd. 2011
Received: 22 June 2011
Accepted: 24 November 2011
Published: 24 November 2011
Fulminant myocarditis frequently results in severe hemodynamic deterioration. High-dose vasopressors or sometimes mechanical circulatory support are required. We report on two cases of fulminant myocarditis successfully treated with pulsatile extracorporeal life support (T-PLS®, Twin Pulse Life support, New heart bio.BHK, Seoul, Korea). With T-PLS, we were able to provide mechanical support to patients until they recovered completely.
Keywordsmyocarditis extracorporeal circulation
We report on two cases of fulminant myocarditis. They developed profound hypoxemia, acidosis, pulmonary edema, and oliguria. T-PLS®(Twin Pulse Life support, New heart bio.BHK, Seoul, Korea) was used in order to prevent further deterioration. Both patients recovered well from fulminant myocarditis with T-PLS support. Echocardiograms showed normal ejection fraction after recovery. Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Inotropics support and T-PLS setting for the initial and weaning period
A 36-year-old women with a history of cardiac surgery for treatment of Tetralogy of fallot 35 years ago and dextrocardia presented to the emergency department with fever and dyspnea for 2 days. On admission, blood pressure was 70/50 mmHg, pulse rate was 120 beats/min, and body temperature was 36.5°C. White blood cell count was 16,470 109/L. EKG demonstrated sinus tachycardia and chest radiography showed pulmonary edema. Troponin I was elevated to 13.72 ng/mL. Echocardiogram showed depressed global left ventricular ejection fraction(28%). The patient was admitted to the intensive care unit. Nine hours after admission, troponin I increased to 42.459 ng/mL. She developed hypoxemia and hemodynamic status showed rapid deterioration with acidosis, oliguria during the subsequent hours, despite a high dose of inotropics and vasopressors. The patient was intubated and T-PLS was initiated with a percutaneous 17 French femoral venous and a 14 French arterial cannula. The pump started with a flow of 1.69 L/min/m2, a pump rate of 70/min, and 100% oxygen flow at 5 L/minute. Arterial blood from the right radial artery was 100% after T-PLS insertion and the patient could be extubated. The membrane oxygenator was replaced on the 3rd, 6th, and 9th days when oxygenation was not adequate. On day 12, blood pressure was 100/60 mmHg, and pulse rate was 80 beats/min, with a T-PLS flow of 1.75 L/min/m2. White blood cell count decreased to 9,240 109/L, and troponin I decreased to 0.130 ng/ml. Arterial blood gas analysis was satisfactory. Left ventricular systolic function (LVEF 52%) and chest x-ray (Figure 1) were much improved. T-PLS was weaned slowly down to off and removed successfully as shown in Table 1. Blood serology showed elevated titers of Coxsackie virus B4 (1:64) and Coxsackie virus B3 (1:32). Forty two days after TPLS, echocardiography showed normal systolic function (LVEF 57%) with mild pericardial effusion. Twelve months later, echocardiography showed normal cardiac function (LVEF 60%).
Fulminant myocarditis is an inflammation of the myocardium, which is caused by viral, bacterial, or protozoal infections, drug toxicity, or immunological reaction . Fulminant myocarditis is characterized by acute onset with severe hemodynamic deterioration. Diagnosis of fulminant myocarditis in the early stages of the disease may be difficult. It may be initially misdiagnosed as septic shock, in which myocardial dysfunction and mild troponin I elevation are commonly seen [1, 2]. Fulminant myocarditis is different from acute myocarditis in its clinical features [1, 3]. Fulminant myocarditis was diagnosed on the basis of clinical features at presentation, including the presence of severe hemodynamic compromise, rapid onset of symptoms, and fever. On the other hand, acute myocarditis usually shows less severe hemodynamic compromise and did not have these features [3, 4].
There is no specific treatment for fulminant myocarditis. Thus, treatment remains supportive. Physicians suspecting fulminant myocarditis must be prepared to use therapeutic options, such as mechanical circulatory support, prior to occurrence of severe organ failure [1, 5, 6]. With appropriate treatment, fulminant myocarditis is commonly reversible within a few days and is associated with better long-term prognosis than acute myocarditis .
Mechanical circulatory support in myocarditis is used for maintenance of cardiac output and organ perfusion, and to minimize the need for inotropic support until myocardial recovery. There are several methods for mechanical circulatory support. These include the intra-aortic balloon pump, non-pulsatile extracorporeal life support, and pulsatile extracorporeal life support, such as T-PLS, which we used for our cases, and ventricular assist devices.
A non-pulsatile pump has advantages over a pulsatile pump in that it maintains regular blood pressure with less hemolysis during total extracorporeal circulation. However, it does not maintain higher pulse pressure or mean blood pressure than the pulsatile pump [7–9], which probably results in less tissue perfusion .
T-PLS is not synchronized with native heart beat. When it is used in severe heart failure patient where there is very low pulsatility from the heart, no synchronization is required. When the heart is recovered and makes higher pulsatility, T-PLS rate is weaned down so that it does not eject too strongly when the heart ejects.
As proven by previous studies, T-PLS can improve coronary and other tissue perfusion with less hemolysis [7, 8, 12], and those advantages are essential for treatment of fulminant myocarditis; therefore, we think that T-PLS is one of the most suitable treatment options for fulminant myocarditis.
- Burian J, Buser P, Eriksson U: Myocarditis; the immunologist's view on pathogenesis and treatment. Swiss med wkly. 2005, 135: 359-364.PubMedGoogle Scholar
- Montcriol A, Wiramus S, Ribeiri A: Successful management of influenza A associated fulminant myocarditis; mobile circulatory support in intensive care unit; a case report. Case J. 2008, 1: 46-10.1186/1757-1626-1-46.View ArticleGoogle Scholar
- Felker GM, Boehmer JP, Hruban RH: Echocardiographic Findings in Fulminant and Acute Myocarditis. J Am Coll Cardiol. 2003, 36: 227-232.View ArticleGoogle Scholar
- Geluk CA, Otterspoor IC, Boeck B: Magnetic resonance imaging in acute myocarditis; a case report and a review of literature. The Netherlands journal of Med. 2002, 60 (5): 223-227.Google Scholar
- Sasaki H, Kawai A, Kuosawa H: Mechanical Support for Patients with Fulminant Acute Myocarditis: Strategy for Biventricular Failure and Respiratory Failure. J Card Surg. 2008, 23: 526-527. 10.1111/j.1540-8191.2008.00602.x.View ArticlePubMedGoogle Scholar
- Shin JS, Lee SW, Han GS: Successful extracorporeal life support in cardiac arrest with recurrent ventricular fibrillation unresponsive to standard cardiopulmonary resuscitation. Resuscitation. 2007, 73: 309-313. 10.1016/j.resuscitation.2006.09.011.View ArticlePubMedGoogle Scholar
- Lee HS, Rho YR, Lee HS: In vivo evaluation of the pulsatile ECLS system. J Artif Organs. 2003, 6 (1): 25-29. 10.1007/s100470300004.View ArticlePubMedGoogle Scholar
- Rho YR, Choi H, Lee JC: Applications of the pulsatile flow versatile ECLS; in vivo studies. Int J Artif Organs. 2003, 26: 428-435.PubMedGoogle Scholar
- Lee DH, Jung TE, Lee JH: Extracorporeal Life Support with a twin-pulse Life Support (T-PLS) System. Korean J Thorac cardiovasc Surg. 2007, 40: 512-516.Google Scholar
- Lee HS, Rho YR, Lee HS: In vivo evaluation of the pulsatile ECLS system. J Artif Organs. 2003, 6: 25-29. 10.1007/s100470300004.View ArticlePubMedGoogle Scholar
- Kim HK, Son HS, Fanc YH: The Effects of Pulsatile Flow Upon Renal Tissue Perfusion During Cardiopulmonary Bypass: A Comparative Study of Pulsatile and Nonpulsatile Flow. ASAIO J. 2005, 51: 30-36. 10.1097/01.MAT.0000150324.02040.B4.View ArticlePubMedGoogle Scholar
- Lee JJ, Lim CH, Son HS: In vitro evaluation of the performance of korean pulsatile ECLS(T-PLS) Using precise Quantification of pressure-Flow Waveforms. ASAIO J. 2005, 51: 604-608. 10.1097/01.mat.0000176240.78374.16.View ArticlePubMedGoogle Scholar
- Lim CH, Son HS, Lee JJ: Optimization of the circuit configuration of a pulsatile ECLS, An In Vivo Experimental study. ASAIO J. 2005, 51: 609-613. 10.1097/01.mat.0000177779.59381.95.View ArticlePubMedGoogle Scholar
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