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How I do it – sole innominate cannulation for acute type A aortic dissection
© Kaul; licensee BioMed Central Ltd. 2012
Received: 18 June 2012
Accepted: 11 October 2012
Published: 20 November 2012
We describe sole direct innominate cannulation for arterial return for establishing both cardiopulmonary bypass and selective antegrade cerebral perfusion in the repair of acute type A dissection and compare it with femoral, axillary, direct aortic and apical cannulations. We believe innominate cannulation has all the advantages of right axillary cannulation and none of its disadvantages. It can be used in all patients in whom innominate artery is not dissected, obstructed, calcified or otherwise diseased.
Acute aortic dissection affects 5.2 people per million per year – twice the rate of ruptured abdominal aortic aneurysm . It has high natural mortality and morbidity . More than 50% with type A dissection die within 48 hours if untreated. There is considerable debate about the ideal sites for cannulation for arterial return for establishment of cardiopulmonary bypass during repair of type A dissection.
The conventional femoral cannulation with retrograde perfusion is known to have an unpredictable but significant risk of atheroembolism, malperfusion and ischemic leg problems in a small number of patients . Right axillary artery cannulation, although increasingly used, requires a separate incision, involves more time, can be difficult if the artery is small and may be associated with low flows and brachial plexus injury. Direct aortic cannulation, whether by conventional technique, Seldinger method or after venous exsanguination followed by aortic transection and true lumen cannulation, carries a risk of aortic rupture and has a higher incidence of stroke and malperfusion [4, 5]. Malperfusion requires rapid sequential resuscitation with cold blood antegrade selective cerebral perfusion (ASCP), cold cardioplegic arrest and lower body perfusion, and can be fatal . Besides, direct true lumen aortic cannuation after venous exsanguination requires a short period of whole body circulatory arrest at normothermia . Transapical cannulation has the disadvantages of significant aortic regurgitation with left ventricular distension and high returns from LV vent and hence a poorer myocardial protection, occasional bleeding from left ventricular apex and an inability to clamp ascending aorta during cooling and hence longer bypass times [6, 7]. Double-padded clamps which allow perfusion through the cannula but clamp aorta and special perfusion cannulae with side channels with tips in left ventricle to manage left ventricular distension  further complicate the technique. Composite cannulation of femoral artery and right axillary artery, while mitigating some of the disadvantages of the individual sites , also, unavoidably, ends up with the risks of both.
We describe innominate artery cannulation for both arterial return and selective antegrade cerebral perfusion for repair of acute type A aortic dissection. This has all the advantages of right axillary artery cannulation and none of the disadvantages. Specifically, it provides selective antegrade cerebral perfusion during lower body circulatory arrest, avoids a separate incision, is quick and can be used in an emergency, avoids brachial plexus injuries and is easy to perform because of the larger size of the artery.
We first described the use of innominate artery during aortic root and arch aneurysm repair in 2009  and have used this cannulation technique for all acute dissection repairs either solely or in a composite manner since. In the rare occasions when innominate artery origin from the arch is dissected or diseased, composite cannulation of femoral artery for arterial return during cardiopulmonary bypass and distal innominate artery or right common carotid artery for ASCP may need to be employed.
In this paper, however, we describe the sole innominate cannulation for the repair of acute type A dissection.
All patients who do not have calcified, dissected or otherwise diseased innominate arteries are suitable. Both radial arteries are monitored for systemic blood pressure. All central venous catheters are placed in the right internal jugular or right subclavian vein in case left innominate vein needs to be sacrificed, which might need to be done rarely. Cerebral oxymetry is used as necessary. TOE is employed in all patients and additional information obtained with respect to dissection flap, aortic regurgitation, hemopericardium and ventricular decompensation, if any. General anaesthesia is used in all patients as usual. Neck, chest, abdomen and legs are prepared and draped. A Y connector is put on the arterial line, one limb of Y connected to a short tubing, and the other limb of Y connected to a long tubing which comes to the right side of the sternotomy for connection to the innominate artery later. The arterial tubing is filled with prime and deaired. The arterial circuit is now ready for either sole or composite innominate cannulation.
Aortic valve, aortic root, coronary ostia and ascending aorta are inspected and a decision taken regarding whether a supracoronary anastomosis with aortic valve resuspension, a Bentall or modified Bentall operation, or a valve sparing remodelling or reimplantation procedure needs to be done. The requisite proximal procedure is completed. By this time whole body temperature has cooled down to 17C. The flow in the IA cannula is momentarily reduced, the IA cannula is withdrawn into the IA and then redirected so that its tip faces towards the IA bifurcation cranially. The flow in the cannula is re-established at 10 ml/kg/min and the tapes on IA, LCCA and LSA gently snugged down. Head is packed in ice and head end of the table lowered. Aortic cross clamp is removed. The LCCA and the LSA tapes are momentarily loosened to inspect the backflow. If backflow is less than copious, LCCA alone or LCCA and LSA are cannulated with DLP cannulae and the two cannulae infused with arterial blood at the rate of 5ml/kg/min while reducing the IA flow to 5ml/kg/min. We try and maintain a right radial pressure around 50 mm Hg even if that involves increasing the total ASCP flow above 10ml/kg/min. Copious backflow from the LCCA and the LSA is suggestive of a competent circle of Willis, and under such circumstance we do not use additional LCCA/LSA ASCP, unless left radial pressure is below 40 mm Hg. If it is elected to use only IA ASCP, additional confirmation regarding left cerebral perfusion can be obtained by cerebral oxymetry. However, we find bilateral radial arterial pressures and backflow rates from LCCA and LSA quite reliable to determine the need for contralateral ASCP.
Patient is slowly rewarmed to 36C. Any additional coronary artery bypass grafting is carried out during rewarming. Bypass is discontinued in the usual manner.
We first described sole innominate cannulation for arterial return and bihemispherical ASCP in a patient with arch and ascending aortic aneurysm with bovine arch variant anatomy in 2009  and have been using sole or composite innominate artery cannulation for repair of acute aortic dissection since . The technique involves introducing a low profile, thin walled cannula through the innominate artery into the proximal arch for instituting cardiopulmonary bypass with antegrade flow in the aorta. The same cannula is redirected cranially to provide antegrade selective cerebral perfusion during lower body deep hypothermic circulatory arrest. Once the repair is complete, the cannula is once again redirected into the arch and whole body circulation resumed. Even when the cannula traverses the proximal IA with its tip in the arch, during total CP bypass, due to the fact that the cannula is less than half of the diameter of the IA, there is sufficient blood going around the cannula from the arch into the innominate artery as evidenced by a normal blood pressure in the right radial cannula and absence of a gradient between right and left radial pressures. Alternately, the cannula may only be redirected cranially or caudally as required without manipulating it in or out of the proximal arch, but we prefer the technique we have described earlier.
Innominate artery cannulation has advantages over all other cannulation techniques.
It provides selective antegrade cerebral perfusion during lower body circulatory arrest as during axillary artery cannulation but avoids a separate incision, can be used quickly in an emergency and avoids brachial plexus injuries. The exposure is easy to perform because of the larger size of the artery and is not made difficult by the size or shape of the patient. It also avoids any vascular complications occasionally associated with a small or thin walled axillary artery.
Compared to femoral artery cannulation, it is quicker to perform, avoids leg incision and avoids the vascular and ischemic complications of leg associated with cannulation and/or long bypass times. It provides antegrade flow at all stages of operation and thus avoids atheroembolism from the abdominal and thoracic aorta in cranial or myocardial circulations, well known with femoral artery cannulation. Innominate cannulation has the additional advantage that aorta can be cross clamped without running the risk of pressurising the false channel further as happens during retrograde flow with femoral arterial cannulation.
IA cannulation avoids the risk of rupture of aorta associated with direct aortic cannulation by conventional or Seldinger techniques. There is no period of circulatory arrest at any temperature with innominate cannulation in contradistinction to a variable period of circulatory arrest at normothermia during direct aortic cannulation after venous exsanguination, aortic transection and true lumen cannulation.
It provides antegrade flow in the arch like the transapical cannulation, but does not affect myocardial preservation owing to aortic regurgitation and ventricular distension encountered almost always with transapical cannulation. Transapical cannulation is associated with higher bypass times as no aortic surgery can be done during the cooling period and so the distal anastomosis cannot start till circulatory arrest has been established and the transapical cannula removed. The distal anastomosis always requires to be done before the proximal anastomosis. Transapical cannulation is also associated with bleeding problems at the apex occasionally.
The innominate cannulation site is always under surgeon’s eye unlike the femoral and the axillary cannulation sites, so that avoidable complications like blood loss and kinking of the cannulae can be detected in time. Also, any extension of dissection into the innominate artery can be visually confirmed and alternate cannulation site chosen, which is why we always employ a Y connector on the arterial line. On the other hand, if right axillary cannulation is used, an innominate dissection might first declare itself as malperfusion at institution of cardiopulmonary bypass . Alternately, innominate artery dissection  or dissection and rupture  presenting as right hemispherical malperfusion might be salvageable by composite femoral and innominate artery perfusion if distal IA is intact  or femoral and right common carotid artery perfusion when distal IA is ruptured .
Svensson et al. reported on stroke risk with different cannulation sites for circulatory arrest in 1336 patients, 24 of which had innominate arterial cannulation and found best results with axillary artery with side graft (299 patients) with mortality of 7% and stroke risk of 4% . Eusanio et al. described the use of brachiocephalic trunk for providing antegrade cerebral perfusion during thoracic aortic surgery. The innominate artery was exposed from its origin to bifurcation and an 8 or 10 mm vascular graft anastomosed to it end to side while it was partially side clamped and the arterial line connected to the vascular graft . They extended the same technique to provision of CPB and ACP in 55 patients requiring various forms of aortic surgery, only 1 of whom had acute dissection, and reported 3.6% hospital mortality and 1.8% temporary neurological dysfunction . Augoustides et al. cannulated innominate artery directly in acute type A dissection and severe thoracic trauma . We first described sole innominate cannulation for arterial return and bihemispherical ASCP employing direct cannulation, without using a vascular graft, in a patient with arch and ascending aortic aneurysm with bovine arch variant anatomy in 2009  and have been using sole or composite innominate artery cannulation for repair of acute aortic dissection as well as arch surgery since. Huang described the use of innominate artery with a side graft during arch surgery, thus obviating the need for manipulation during bypass . However, side clamping of the artery at normothermia is required and there is occasional bleeding from the suture line or weeping from the graft. Shi et al. reported 46 cases with repair of type A dissection with ascending aorta and hemiarch replacement combined with stent graft elephant trunk technique using direct innominate cannulation with a 22 or 24 F short-tipped right angled cannula without advancing the cannula into the arch. Operative mortality was 2.2%, there were no strokes and TND grade 2 or above was 6.6% .
In conclusion, innominate cannulation can be used in all patients with acute type A dissection for both arterial return and antegrade selective cerebral perfusion unless innominate artery is calcified, dissected or obstructed. The tip of the cannula is insinuated into the arch during CP bypass and cranially towards innominate bifurcation during antegrade selective perfusion. This technique can be used for all open heart surgery when direct aortic cannulation is not feasible and is particularly useful in acute ascending aortic dissections and aortic arch surgery.
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