- Case report
- Open Access
- Open Peer Review
Bronchial sleeve resection for early-stage squamous cell carcinoma
© Goto et al; licensee BioMed Central Ltd. 2012
- Received: 25 September 2011
- Accepted: 17 April 2012
- Published: 17 April 2012
A 75-year-old man complained of sputum and was referred to our department. His sputum cytology was class III. Chest X-ray and computed tomography showed no abnormalities, but bronchoscopy revealed an elevated lesion in the membranous portion of the left main bronchus, which was pathologically diagnosed as squamous cell carcinoma in situ. Since bronchoscopy revealed no other lesions in the visible parts of the airway, it was considered to be a solitary, early lung cancer, and sleeve resection of the left main bronchus was performed. The postoperative pathological diagnosis was squamous cell carcinoma in situ, pTisN0M0, stage 0. In recent years, an increasing number of studies have reported photodynamic therapy and brachytherapy for the treatment of early lung cancer. However, aggressive bronchoplastic surgery with emphasis on curability should be considered for lesions that are deemed resectable based on their number and extent of invasion.
- Early-stage lung cancer
- Bronchial sleeve resection
As mass screening for lung cancer has become more widespread and bronchoscopy has advanced, the number of patients diagnosed with early lung cancer has increased . However, the location and number of early lung cancers vary among the patients. Because of this and the diversification of therapeutic approaches, no standard treatment has been established to date. Early lung cancer is sometimes confined to the central portion at a distance from the lung parenchyma and, in such cases, curative treatment is possible by resecting the affected bronchus alone, while preserving the lung parenchyma. Herein, we report a patient who underwent sleeve resection of the left main bronchus for a centrally located, solitary, early lung cancer.
The Japan Lung Cancer Society (JLCS) has proposed their own sets of criteria for early lung cancer , although an internationally accepted set of criteria has not yet been determined. The JLCS defined early lung cancers as tumors that fulfill the following criteria: 1) chest X-ray findings are normal, 2) no lymph node or distant metastases are detectable using common methods for cancer staging, 3) the lesion is localized between the trachea and subsegmental bronchus, 4) the distal margin of the lesion is endoscopically visible, 5) the lesion is less than 2 cm in diameter, and 6) histologically, the lesion is squamous cell carcinoma . Early lung cancer is located at sites that can be directly viewed through a bronchoscope; therefore, many surgeons recommend noninvasive treatments such as photodynamic therapy and endobronchial brachytherapy [3, 4]. The patient’s poor general condition and presence of multiple lesions are good indications for these therapies . However, these treatments presuppose accurate tumor staging, including lymph node metastasis, and their effects have not been verified. Moreover, medical equipment for these therapies is available in only a few centers, and the number of patients who can receive such treatments is currently very small. On the other hand, the main advantage of surgery is its optimal local control. In addition, surgery allows the accurate pathological evaluation of cancer invasion and presence of lymph node metastasis. Surgery also allows us to change surgical procedures based on the results of intraoperative frozen-section analysis and intraoperative findings, thereby increasing the curability. In recent years, advances in endobronchial ultrasonography have made it possible to histologically diagnose mediastinal lymph node metastases before surgery . However, it remains difficult to definitively diagnose sub- and para-aortic lymph node metastases preoperatively. In the present patient, intraoperative pathological examination confirmed the absence of lymph node metastases, including the sub- and para-aortic lymph nodes.
Standard lobectomy or sleeve lobectomy is a usual surgical technique for early hilar lung cancer originating from lobar or segmental bronchi . On the other hand, a lung-saving procedure is usually indicated for central tumors, for which the alternative is a pneumonectomy. It preserves normal lung tissue, reduces serious postoperative complications, and may enable the resection of cancer in selected patients with an inadequate reserve . Many patients with early lung cancer are heavy smokers, frequently complicated by obstructive ventilatory disturbance, and develop multiple lung cancers synchronously or metachronously . Surgery preserving the lung function as much as possible seems to be useful in terms of the quality of life and possibility of re-operation .
In conclusion, we report a case of early lung cancer arising from the left main bronchus, in which sleeve resection of the left main bronchus was performed. We believe that this procedure allows the curative resection of cancer while preserving the lung function. For the early detection of a second incidence of primary hilar tumor, repeated sputum cytology and bronchoscopy will be mandatory .
Written informed consent was obtained from patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Watanabe Y, Murakami S, Oda M, Ohta Y, Watanabe S, Nozaki Z, Kamimura R, Kobayashi T, Nonomura A, Minato H: Surgical management of early stage central (hilar) and peripheral nonsmall cell lung carcinoma. Cancer. 2000, 89: 2438-2444. 10.1002/1097-0142(20001201)89:11+<2438::AID-CNCR18>3.0.CO;2-Q.View ArticlePubMedGoogle Scholar
- The Japan Lung Cancer Society: General Rule for Clinical and Pathological Record of Lung Cancer. 2010, Tokyo: Kanehara Press, 7thGoogle Scholar
- Cortese DA, Edell ES, Kinsey JH: Photodynamic therapy for early stage squamous cell carcinoma of the lung. Mayo Clin Proc. 1997, 72: 595-602.View ArticlePubMedGoogle Scholar
- Saito M, Yokoyama A, Kurita Y, Uematsu T, Miyao H, Fujimori K: Treatment of roentogenographically occult endobronchial carcinoma with external beam radiotherapy and intraluminal low dose rate brachytherapy. Int J Radiat Oncol Biol Phys. 1996, 34: 1029-1035. 10.1016/0360-3016(95)02390-9.View ArticlePubMedGoogle Scholar
- van Boxem AJ, Westerga J, Venmans BJ, Postmus PE, Sutedja G: Photodynamic therapy, Nd-YAG laser and electrocautery for treating early-stage intraluminal cancer: which to choose?. Lung Cancer. 2001, 31: 31-36. 10.1016/S0169-5002(00)00154-9.View ArticlePubMedGoogle Scholar
- Nakajima T, Yasufuku K, Nakajima M, Baba M, Yoshikawa K, Kamada T, Hiroshima K, Nakatani Y, Fujisawa T, Yoshino I: Endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with non-small cell lung cancer in non-operable patients pursuing radiotherapy as a primary treatment. J Thorac Oncol. 2010, 5: 606-611.View ArticlePubMedGoogle Scholar
- Ferguson MK, Lehman AG: Sleeve lobectomy or pneumonectomy: optimal management strategy using decision analysis techniques. Ann Thorac Surg. 2003, 76: 1782-1788. 10.1016/S0003-4975(03)01243-8.View ArticlePubMedGoogle Scholar
- Icard P, Regnard JF, Guibert L, Magdeleinat P, Jauffret B, Levasseur P: Survival and prognostic factors in patients undergoing parenchymal saving bronchoplastic operation for primary lung cancer: a series of 110 consecutive cases. Eur J Cardiothorac Surg. 1999, 15: 426-432. 10.1016/S1010-7940(99)00048-2.View ArticlePubMedGoogle Scholar
- Usuda J, Ichinose S, Ishizumi T, Hayashi H, Ohtani K, Maehara S, Ono S, Kajiwara N, Uchida O, Tsutsui H, Ohira T, Kato H, Ikeda N: Management of multiple primary lung cancer in patients with centrally located early cancer lesions. J Thorac Oncol. 2010, 5: 62-68. 10.1097/JTO.0b013e3181c42287.View ArticlePubMedGoogle Scholar
- Handy JR, Asaph JW, Skokan L, Reed CE, Koh S, Brooks G, Douville EC, Tsen AC, Ott GY, Silvestri GA: What happens to patients undergoing lung cancer surgery? Outcomes and quality of life before and after surgery. Chest. 2002, 122: 21-30. 10.1378/chest.122.1.21.View ArticlePubMedGoogle Scholar
- Johnson BE: Second lung cancers in patients after treatment for an initial lung cancer. J Natl Cancer Inst. 1998, 90: 1335-1345. 10.1093/jnci/90.18.1335.View ArticlePubMedGoogle Scholar
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