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Massive pulmonary embolism secondary to longstanding traumatic femoropopliteal pseudoaneurysm associated with arteriovenous fistula
© Darwazah et al.; licensee BioMed Central Ltd. 2014
Received: 28 September 2013
Accepted: 17 February 2014
Published: 22 February 2014
Pulmonary embolism is a common clinical condition associated with high mortality.
The majority of pulmonary emboli originate from deep venous thrombosis in the popliteal and femoral veins.
We present a rare case of a 21-year-old caucasian male patient with massive pulmonary embolism. The source of emboli originated from thrombosed femoropopliteal pseudoaneurysm associated with arteriovenous fistula which was caused by a bullet injury 7 years before. The patient underwent successful surgical pulmonary embolectomy followed by aneurysmectomy with reconstruction of femoral and popliteal vessels.
Various therapeutic options are available including anticoagulation, thrombolysis, catheter embolectomy and surgery.
We report a young patient with massive PE associated with peripheral pseudoaneurysm. Both conditions were treated successfully by surgical intervention.
A 21-year-old caucasian male patient was referred as an emergency case of massive pulmonary embolism.
Two days before admission, the patient had epigastric pain and vomiting. He was diagnosed as having gastritis and was treated accordingly.
Twelve hours after observation, his condition deteriorated due to chest pain and tachypnea. Blood pressure was 90/60 mmHg with regular pulse of 120. Respiratory rate was 22 breath/ min. with oxygen saturation of 80% at room air.
Electrocardiography showed sinus tachycardia, large S wave in lead I, inverted T wave in Lead III and incomplete right BBB. Cardiac enzymes, troponin, and D-dimer were all negative.
Acute pulmonary embolism was suspected despite the fact that D-dimer was negative and the patient had no past history of DVT or recent operation or trauma. However, the patient gave a history of a gunshot to the right thigh when he was 14 years old.
Echocardiography showed severe dilatation of the right ventricle, atrium and pulmonary artery with no evidence of emboli. Tricuspid valve was severely incompetent with PAP of 55 mmHg.
On arrival, the patient was immediately transferred to the operating room due to hemodynamic instability (BP 60/40 mmHg, pulse 140, CVP 22 mmHg and high respiratory rate).
The patient remained hemodynamically stable postoperatively receiving minimal inotropic support and heparin infusion.
The patient was discharged home after two weeks receiving aspirin and marivan.
Pulmonary embolism (PE) is a common clinical condition with an estimated incidence of 2.3 per 10,000 .
Despite advances in diagnosis and therapy, it is still associated with high mortality. In severe cases with massive PE mortality rate may reach up to 52% .
The main therapy of PE is anticoagulation using heparin. However, in severe cases of massive or submassive occlusion of PA such treatment is insufficient.
Thrombolytic therapy is considered to be the first line of treatment of PE . Thrombolysis causes rapid resolution of pulmonary emboli and subsequent restoration of hemodynamic stability, and right ventricular function .
Minimal invasive technique using catheter embolectomy is effective in removal of clots and recovery of right ventricular function. However, it is associated with recurrence of pulmonary emboli, pulmonary hypertension, hemorrhage, injury and perforation of pulmonary arteries .
Surgical pulmonary embolectomy has been traditionally reserved as a last resort of treatment. It is commonly employed in patients with massive PE with cardiogenic shock or among those with failed medical therapy. The early results were disappointing due to high mortality rate reaching 60% .
Recently, the concept of using surgery has been changed. Its indications expanded to include more stable patients. The rationale behind such change was based on the importance of right ventricular function in determining early and late survival. The mortality rate of patients with RV failure undergoing surgery may reach 30%, while patients with cardiogenic shock or previous preoperative cardiac arrest the mortality increases to 70% .
Various studies showed a significant reduction of mortality between 3.8-6% when surgical intervention was performed early among unstable patients with massive PE or in stable patients with submassive PE with RV dysfunction [4, 7].
The precise diagnosis of PE in our patient was obtained by CT angiography. Although, transthoracic echocardiography failed to visualize PA emboli, the data obtained regarding RV dilatation, PA dilatation, pulmonary hypertension and severe tricuspid regurgitation were important to suspect PE and subsequently to commence early treatment and to perform further investigations.
Our decision to perform early surgery was based on the previous observation of the above studies. Our patient had a massive left PA embolism, his hemodynamic parameters drastically changed on arrival and there was evidence of RV dysfunction on echocardiography.
Although the current guidelines recommended the use of thrombolytic agents in massive PE, such modality of treatment was not used primarily due to hemodynamic instability of the patient, moreover the outcome of surgery after possible failure of thrombolytic therapy is associated with high mortality.
The use of inferior vena cava filters after pulmonary embolectomy is debatable. Various studies [7, 8], recommended its routine use to prevent recurrent pulmonary emboli. While, others  have demonstrated no evidence of recurrent emboli in absence of these filters. In the present case, IVC filters were not used as the patient was already anticoagulated and the source of PE originated from the thrombosed pseudoaneurysm and not from the deep venous system.
Among the previously operated patients with PE, the risks of developing embolisation was related to recent trauma or surgery, malignancy, hypercoagulable conditions, immobility, pregnancy and the presence of deep vein thrombosis . In 20% of cases, no obvious risk factor could be detected .
The risk factor for the development of PE in our patient was rather interesting. The source of emboli came from a thrombosed femoropopliteal pseudoaneurysm which was associated with fistulous connection with the femoral vein caused by a bullet injury. The initial vascular trauma was clinically unrecognised and presented several years later.
The thrombotic material traversed across the A-V fistula to reach the pulmonary artery instead of showering distally. This unusual route was facilitated by the associated injury of the popliteal artery at the initial trauma. As seen by preoperative CT angiography, the distal end of the injured popliteal artery was extremely narrowed. This prevented distal embolisation and created more pressure inside the pseudoaneurysm, thus forcing emboli across the large fistula to reach pulmonary artery.
Both A-V fistula and pseudoaneurysm formation are well recognized complications of vascular trauma. Early recognition and repair can avoid such complications. Longstanding A-V fistula causes irreversible degenerative changes in the arterial wall causing pseudoaneurysm formation and thrombosis, dilatation of the involved veins, congestive heart failure, limb oedema and ischemia. The development of pseudoaneurysm may appear years after trauma and can develop with or without repair of traumatic A-V fistula [6, 10]. These patients often present with peripheral arterial occlusion and intermittent claudication .
Treatment of traumatic pseudoaneurysm with A-V fistula is surgical resection and primary repair. In neglected cases, surgery is often difficult and associated with high incidence of bleeding. Under such circumstances, stent graft implantation is an effective alternative technique .
Our decision to perform surgery was due to the presence of thrombosis inside the aneurysm, extension of the aneurysm to involve the popliteal artery with narrowing of its distal end and the young age of the patient.
Surgical excision and repair was not easy due to the presence of extensive adhesions and congested vessels. However, meticulous technique was sufficient to obtain the best outcome.
Massive PE may rarely occur secondary to thrombosed femoropopliteal psuedoaneurysm associated with fistula. The early diagnosis and quick decision to perform surgery is associated with a high success rate.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Goldhaber SZ, Visani L, De Rosa M: Acute pulmonary embolism. Clinical outcomes in the International Cooperative pulmonary embolism Registry (ICOPER). Lancet. 1999, 353: 1386-1389. 10.1016/S0140-6736(98)07534-5.View ArticlePubMedGoogle Scholar
- Dauphine C, Omari B: Pulmonary embolectomy for acute masive pulmonary embolism. Ann Thorac Surg. 2005, 79: 1240-1244. 10.1016/j.athoracsur.2004.08.081.View ArticlePubMedGoogle Scholar
- Aymard T, Kadner A, Widmer A, Basciani R, Tevaearai H, Weber A, Schmidii J, Carrel T: Massive pulmonary embolism: surgical embolectomy versus thrombolytic therapy-should surgical indications be revisited?. Eur J Cardiothorac Surg. 2013, 43 (1): 90-94. 10.1093/ejcts/ezs123.View ArticlePubMedGoogle Scholar
- Samoukovic G, Malas T, de Varennes B: The role of pulmonary embolectomy in the treatment of acute pulmonary embolism: a literature review from 1968 to 2008. Interact Cardiovasc Thorac Surg. 2010, 11 (3): 265-270. 10.1510/icvts.2009.228361.View ArticlePubMedGoogle Scholar
- Kearon C, Kahn SR, Agnelli G, Goldhader S, Raskob GE, Comerota AJ: American College of Chest Physicians. Antithrombotic therapy for venous thromboembolic disease. Chest. 2008, 133 (6 Suppl): 454S-545S.View ArticlePubMedGoogle Scholar
- Hartung O, Garcia S, Alimi YS, Juhan C: Exensive arterial aneurysm developing after surgical closue of longsanding post-traumaic popliteal arteriovenous fistula. J Vasc Surg. 2004, 39 (4): 889-892. 10.1016/j.jvs.2003.10.059.View ArticlePubMedGoogle Scholar
- Leacche M, Unic D, Goldhaber SZ, Rawn JD, Aranki SF, Couper GS, Milhaljevic T, Rizzo RJ, Cohn LH, Aklog L, Byrne JG: Modern surgical treatment of massive pulmonary embolism: results in 47 consecutive patients after rapid diagnosis and aggressive surgical approach. J Thorac Cardiovasc Surg. 2005, 129: 1018-1023. 10.1016/j.jtcvs.2004.10.023.View ArticlePubMedGoogle Scholar
- Rosenberger P, Shernan SK, Rawn JD, Scott J, Eltzschig HK: Critical role of inferior vena caval filter placement after pulmonary embolectomy. J Card Surg. 2005, 20: 289-290. 10.1111/j.1540-8191.2005.200426.x.View ArticlePubMedGoogle Scholar
- Kadner A, Schmidli J, Schcnhoff F, Krahenbuhl E, Immer F, Carrel T, Eckstein F: Excellent outcome after surgical treatment of massive pulmonary embolism in critically ill patients. J Thorac Cardiovasc Surg. 2008, 136: 448-451. 10.1016/j.jtcvs.2007.11.021.View ArticlePubMedGoogle Scholar
- Kotelis D, Klemm K, von Tengg-Kobligk H, Allenberg JR, Böckler D: Intermittent claudications secondary to a traumatic arteriovenous fistula. Vasa. 2007, 36 (4): 285-287. 10.1024/0301-1518.104.22.1685.View ArticlePubMedGoogle Scholar
- Önal B, Ilgit ET, Kosar S, Akkan K, Gumus T, Akpek S: Endovascular treament of peripheral vacular lesions with stent-grafts. Diagn Interv Radiol. 2005, 11 (3): 170-174.PubMedGoogle Scholar
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