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  • Letter to the Editor
  • Open Access

Constrictive pericarditis complicating cardiac transplantation

  • 1Email author,
  • 2,
  • 2,
  • 2 and
  • 3
Journal of Cardiothoracic Surgery201510:109

  • Received: 16 July 2015
  • Accepted: 3 August 2015
  • Published:


Constrictive pericarditis is a disease characterized by progressive pericardial fibrosis. If left untreated it can lead to progressive heart failure and can be severely disabling. Medical management with non-steroidal anti-inflammatory drugs in combination with colchicine is promising in the acute phase of the disease but for more chronic cases pericardiectomy offers the best chance for hemodynamic recovery. Constrictive pericarditis after cardiac transplantation is a rare phenomenon. Current literature suggests that early pericardiectomy may be the most effective treatment in this subset of patients as well.


  • Constrictive pericarditis
  • Pericardiectomy
  • Cardiac transplant

To the Editor

We read with great interest the recently published article byZhu et al. in the Journal of Cardiothoracic Surgery [1]. The authors have provided valuable insight regarding the role of pericardiectomy in constrictive pericarditis. Their mortality rate of 5.4 % falls on the lower end of the spectrum in reported literature and their one year survival rate of 92 % speaks volume of the excellent results that can be achieved in high volume centers [1]. However, we wish to highlight a few important points relevant to the article.

A relatively newer and less known development of constrictive pericarditis is seen recently after cardiac transplantation. This is an unusual presentation as the transplanted heart is believed to be free of any pericardial tissue. The data on this entity is very limited but judging from the few published case reports, pericardiectomy offers the only chance of successful physiologic recovery in this subset of patients [2, 3]. We would like to inquire whether Zhu and colleagues encountered patients with post cardiac transplant constrictive pericarditis in their cohort in the subgroups including indeterminate (n = 106 patients) and post-surgery (n = 19 patients) as indicated in Table one of their manuscript [1].

Pericardiectomy is a well established treatment for sub acute to long-standing constrictive pericarditis [4]. However, a subset of patients affected with acute constrictive pericarditis may only experience transient constriction and may benefit from only medical management with non-steroidal anti-inflammatory drugs and/or colchicine for 2 to 3 months duration. We wonder if a similar therapeutic algorithm was used in their study especially in the patients presenting with acute constrictive physiology? We would appreciate if the authors could share their invaluable experience on these subgroup of patients.



We would like to thank Dr Sarah Aftab Ahmad, Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, USA for proof reading and editing the manuscript.

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

Department of Surgery, Saint Francis Hospital and Medical Center, University of Connecticut Health Center, Hartford, CT, USA
Hartford Hospital, University of Connecticut Health Center, Hartford, CT, USA
Saint Vincent Hospital, University of Massachusetts Medical School, Worcester, MA, USA


  1. Zhu P, Mai M, Wu R, Lu C, Fan R, Zheng S. Pericardiectomy for constrictive pericarditis: single-center experience in China. J Cardiothorac Surg. 2015;10:34.View ArticlePubMedPubMed CentralGoogle Scholar
  2. Roca J, Manito N, Castells E, Miralles A, Mauri J, Saura E, et al. Constrictive pericarditis after heart transplantation: report of two cases. J Heart Lung Transplant. 1995;14:1006–10.Google Scholar
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  4. Maisch B, Seferovic PM, Ristic AD, Erbel R, Rienmuller R, Adler Y, et al. Task force on the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology. Guidelines on the diagnosis and management of pericardial diseases: executive summary. Eur Heart J. 2004;25:587–610.Google Scholar


© Umer et al. 2015