- Case report
- Open Access
- Open Peer Review
Thoracoscopic lobectomy for pulmonary vein occlusion after radiofrequency catheter ablation of atrial fibrillation
© Lo et al. 2016
- Received: 17 November 2015
- Accepted: 10 January 2016
- Published: 19 January 2016
Radiofrequency catheter ablation for paroxysmal atrial fibrillation is well established but not drawback free. Pulmonary vein stenosis is one of the complications and usually treated with stenting with the disadvantages of high re-stenosis rate and anticoagulant dependence.
Herein, we present the case of a 47 year-old lady, who suffered from fever and hemoptysis due to right inferior pulmonary vein occlusion after radiofrequency catheter ablation for paroxysmal atrial fibrillation. Eventually, thoracoscopic right lower lung lobectomy was inevitable with satisfactory result.
Pulmonary vein stenosis is a major complication after radiofrequency ablation of atrial fibrillation. High suspicion and early detection in patients with pulmonary manifestations are mandatory for salvage the injured lung in early. If delayed, surgical resection of the involved lung, especially through the thoracoscopic approach will eradicate the problem with minimal complication.
- Atrial fibrillation
- Radiofrequency catheter ablation
- Thoracoscopic lobectomy
Radiofrequency catheter ablation is one of the recommended therapeutic options for the paroxysmal atrial fibrillation with low complication rate and promising success rate. However, pulmonary vein stenosis is one of the major complications of this procedure and could be fatal . Hemoptysis, dyspnea, intractable cough, and recurrent pneumonia are the most common manifestations . Radical procedure like lobectomy may be necessary in the case of medical treatment failure, recurrent pneumonia or sepsis [3, 4]. We reported on a 47 year-old lady with recurrent pulmonary events after radiofrequency catheter ablation of paroxysmal atrial fibrillation. The diagnosis of right inferior pulmonary vein occlusion was delayed and eventually, thoracoscopic right lower lung lobectomy was inevitable with satisfactory result.
A 47 year-old barber lady with three-year history of paroxysmal atrial fibrillation was admitted on 2 June 2013 for recent incremental attacks of palpitation. Physical examination and laboratory tests were all unremarkable. On 4 June 2013, the electrophysiological study using EnSiteTM VelocityTM (St. Jude Medical One St. Jude Medical Drive, St. Paul, MN 55117 USA) through the transseptal approach confirmed that the paroxysmal atrial fibrillation was originating from the right superior and inferior pulmonary veins. Subsequently, 20–30 Watts (45° Celsius for 30 to 40 s) of radiofrequency energy was applied to atrial locations of the four pulmonary veins utilizing a 7 F quadripolar irrigating ablation catheter. The successful ablation was confirmed by complete antegrade and retrograde electrophysiological study using incremental pacing and extrastimulus technique during isoproterenol administration. The patient was discharged six days later with uneventful course until 10 September 2013, a febrile episode associated with productive cough and mild dyspnea happened. Right lower lobe pneumonia was found by chest roentgenography and computed tomography. The patient was discharged in improved condition after antibiotic treatment for two weeks.
On the microscopic examination, extensive hemorrhagic necrosis with acute and chronic inflammatory cell infiltration, interstitial fibrosis, and vascular thrombosis were noted around the right inferior pulmonary vein.
Besides the medical rate control and surgical ablation, radiofrequency catheter ablation is another therapeutic option for the paroxysmal atrial fibrillation with intractable symptoms. The procedure related overall complication rate is 6.29 %. Among them, the cardiac complications include myocardial infarction, pericardial complications and various iatrogenic cardiac injuries had been reported. The pulmonary vein injury is one of the major adverse events of this procedure [1–3].
Pulmonary vein stenosis can be under-recognized because the manifestations are often obscure in the early stage or in cases with limited involvement. Repetitive or progressive deterioration of non-specific respiratory manifestations suggest that the iatrogenic pulmonary vein stenosis getting significant. The first 2 cases of pulmonary vein stenosis after radiofrequency ablation of atrial fibrillation were successfully treated with balloon dilation . Since then, this complication is usually treated with percutaneous transluminal pulmonary vein balloon dilatation or stenting with the demerits of significant re-stenosis rate and need of long-term antithrombotic therapy . In the limited cases with irreversible occlusion with significant symptoms, dilation and stenting can be not effective and eventually requiring pulmonary resection [4, 6, 7].
In our patient, because of the totally occluded pulmonary vein, the percutaneous transluminal approach was aborted and the surgical resection of the injured lung would be the final option. Certainly, this method would eradicate the lesion on the cost of sacrifice of pulmonary capacity. Otherwise, although technically demanding, surgical pulmonary venous angioplasty might be another salvage option. However, in the chronic case with severe inflammatory adhesion, this procedure might be impossible. Furthermore, the injury created by the radiofrequency energy was reported to result in irreversible venous and arterial medial thickening and intimal hyperplasia throughout the lung with consolidation that prohibited the lung sparing strategies .
In conclusion, pulmonary vein stenosis is a major complication after radiofrequency ablation of atrial fibrillation. High suspicion and early detection in patients with pulmonary manifestations are mandatory for salvage the injured lung in early. If delayed, surgical resection of the involved lung, especially through the thoracoscopic approach will eradicate the problem with minimal complication.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. This case study was approved by Institutional Review Board for Kaohsiung Chang Gung Memorial Hospital (104-7429B).
The authors have no funding, financial relationships or conflicts of interest disclosure.
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- Gupta A, Perera T, Ganesan A, Sullivan T, Lau DH, Roberts-Thompson KC, et al. Complications of catheter ablation of atrial fibrillation: a systematic review. Circ Arrhythm Electrophysiol. 2013;6:1082–8.PubMedView ArticleGoogle Scholar
- Holmes Jr DR, Monahan KH, Packer D. Pulmonary vein stenosis complicating ablation for atrial fibrillation: clinical spectrum and interventional considerations. JACC Cardiovasc Interv. 2009;2:267–76.PubMedView ArticleGoogle Scholar
- Deshmukh A, Patel NJ, Pant S, Shah N, Chothani A, Mehta K, et al. In-hospital complications associated with catheter ablation of atrial fibrillation in the United States between 2000 and 2010: analysis of 93 801 procedures. Circulation. 2013;128:2104–12.PubMedView ArticleGoogle Scholar
- Libretti L, Ciriaco P, Zannini P. Pulmonary vein stenosis requiring lobectomy after radiofrequency catheter ablation for atrial fibrillation. J Cardiovasc Surg. 2012;53:821–3.Google Scholar
- Robbins IM, Colvin EV, Doyle TP, Kemp WE, Loyd JE, McMahon WS, et al. Pulmonary vein stenosis after catheter ablation of atrial fibrillation. Circulation. 1998;98:I769–75.View ArticleGoogle Scholar
- Yang HM, Lai CK, Patel J, Moore J, Chen PS, Shivkumar K, et al. Irreversible intrapulmonary vascular changes after pulmonary vein stenosis complicating catheter ablation for atrial fibrillation. Cardiovasc Pathol. 2007;16:51–5.PubMedView ArticleGoogle Scholar
- Steliga MA, Ghouri M, Massumi A, Reul RM. Lobectomy for pulmonary vein occlusion secondary to radiofrequency ablation. J Cardiovasc Electrophysiol. 2010;21:1055–8.PubMedView ArticleGoogle Scholar