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Thoracoscopic lobectomy for lung cancer in a patient with a partial anomalous pulmonary venous connection: a case report
© The Author(s). 2016
Received: 24 March 2016
Accepted: 28 July 2016
Published: 2 August 2016
A partial anomalous pulmonary venous connection is a rare congenital defect in which blood from the pulmonary vein is returned to the right atrium. Asymptomatic patients with a partial anomalous pulmonary venous connection with a small left-to-right shunt do not require surgical treatment. If such patients require a major lung resection, the surgical procedure could precipitate fetal right heart failure if the anomalous venous connection remains uncorrected.
A 59-year-old man was found to have an abnormal shadow on chest roentgenogram. Chest computed tomography imaging showed a mass in the right upper lobe. At the same time, we incidentally found an anomalous vessel. We diagnosed the abnormality as a partial anomalous pulmonary venous connection. Because the mass may have been lung cancer, a right upper lobectomy was performed using video-assisted thoracoscopic surgery. The right upper lobe vein drained into the superior vena cava. The anomaly was not corrected and the surgery was successful. His postoperative course was uneventful without cardiac failure.
Before performing a major lung resection, surgeons should be aware of this rare anomaly and carefully interpret clinical images of all pulmonary veins.
A partial anomalous pulmonary venous connection (PAPVC) is a rare congenital defect in which the right atrium is the point of return for blood from the pulmonary vein. This anomaly is often associated with other congenital heart defects, especially atrial septal defects. Asymptomatic patients with a PAPVC with a small left-to-right shunt do not require surgical treatment. However, if patients with PAPVC require a major lung resection, the surgical procedure could precipitate fetal right heart failure if the PAPVC is not corrected [1, 2]. In this article, we present a case of right PAPVC that was diagnosed during preoperative examinations for lung cancer.
A PAPVC is a relatively uncommon congenital anomaly that is detected in only 0.4–0.7 % of the general population at the time of autopsy [1–3]. These anomalies are often associated with other congenital heart defects, especially atrial septal defects, in 80–90 % of patients . A PAPVC results in the recirculation of oxygenated pulmonary venous blood through the pulmonary veins (i.e., left-to-right shunt).
Surgical treatment of a PAPVC is recommended for patients with a Qp/Qs greater than 2.0, regardless of associated cardiac defects . In practice, the amount of left- to-right shunt is usually small; therefore, clinical manifestations such as fatigue, dyspnea, syncope, atrial arrhythmias, right heart failure, and pulmonary hypertension rarely occur . However, in patients with lung cancer, this anomaly may present some serious problems. If lung cancer is in a lobe that has the abnormal vein, surgical resection is sufficient treatment. On the other hand, if the PAPVC is in a different lobe, a major lung resection could increase the volume of shunt flow and cause right-sided heart failure. Therefore, it is critical to correct this anomaly to prevent heart failure.
In patients with lung cancer, a PAPVC on the left side is corrected by a simple end-to-side anastomosis to the left auricular appendage or the left atrium, or by an end-to-end anastomosis to the stump of the resected normal pulmonary vein without extracorporeal circulation . When the PAPVC is located on the right side, a cardiopulmonary bypass is usually required because of the shortness of the anomalous vein.
Black and associates  reported a patient who had fetal right heart failure after undergoing right pneumonectomy for lung cancer with a missed contralateral PAPVC. Sakurai and associates  reported a case of right PAPVC repair using cardiopulmonary bypass before left pneumonectomy; the patient had an uneventful course. Takei and associates  similarly reported a case of an anomalous pulmonary vein of the left upper lobe that was separated from the left brachiocephalic vein and anastomosed to the stump of the inferior pulmonary vein.
Therefore, before performing a major lung resection, surgeons must always consider the possible presence of a PAPVC and carefully interpret the CT imaging of all pulmonary veins. If an anomalous vein is incidentally detected during a surgery for lung cancer or the patient develops unexplained fetal right heart failure after the surgery, it is important to reinterpret the preoperative CT images and discuss carefully whether to perform a revascularization procedure while considering a PAPVC.
We experienced a patient with a PAPVC and primary lung cancer in the same lobe, which was successfully treated by lobectomy. Before performing any major lung resection, surgeons should be aware of this rare anomaly and carefully interpret the clinical images of all pulmonary veins of the resected and the nonresected pulmonary lobes.
CT, computed tomography; FDG, 18F-fluorodeoxyglucose; PaCO2, partial pressure of arterial carbon dioxide; PaO2, partial pressure of arterial oxygen; PAPVC, partial anomalous pulmonary venous connection; SVC, superior vena cava
Availability of data and materials
The data supporting the conclusions of this article are included within the article.
KI is the corresponding author and carried out revision of the manuscript. TM participated in the surgery, and supervised the writing of the manuscript. HA and KK participated in the clinical treatments. MM supervised the writing of the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of the Journal of Cardiothoracic Surgery.
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- Black MD, Shamji FM, Goldstein W, Sachs HJ. Pulmonary resection and contralateral anomalous venous drainage: a lethal combination. Ann Thorac Surg. 1992;53:689–91.View ArticlePubMedGoogle Scholar
- Hughes CW, Rumore PC. Anomalous pulmonary veins. Arch Pathol. 1944;37:364–7.Google Scholar
- Healey Jr JE. An anatomic survey of anomalous pulmonary veins: their clinical significance. J Thorac Surg. 1952;23:433–44.PubMedGoogle Scholar
- Tourmousoglou C, Kalogeropoulou C, Koletsis E, Charoulis N, Prokakis C, Alexopoulos P, et al. Right upper lobe partial anomalous pulmonary venous connection. Case Rep Vasc Med 2014: doi:10.1155/2014/249896
- Hijii T, Fukushige J, Hara T. Diagnosis and management of partial anomalous pulmonary venous connection. Cardiology. 1998;89:148–51.View ArticlePubMedGoogle Scholar
- Mikubo M, Ikeda S, Hoshino T, Yokota T, Fujii A, Mori M, et al. Pulmonary resection of lung cancer in a patient with partial anomalous pulmonary venous connection. Ann Thorac Surg. 2013;95:1799–801.View ArticlePubMedGoogle Scholar
- Sakurai H, Kondo H, Sekiguchi A, Naruse Y, Makuuchi H, Makuuchi H, et al. Left pneumonectomy for lung cancer after correction of contralateral partial anomalous pulmonary venous return. Ann Thorac Surg. 2005;79:1778–80.View ArticlePubMedGoogle Scholar
- Takei H, Suzuki K, Asamura H, Kondo H, Tsuchiya R. Successful pulmonary resection of lung cancer in a patient with partial anomalous pulmonary venous connection: report of a case. Surg Today. 2002;32:899–901.View ArticlePubMedGoogle Scholar