Skip to main content

Perigraft abscess after DeBakey type-1 aortic dissection: a case report



Perigraft abscess is a rare condition which constitutes a small proportion of aortic graft infection (AGI). Early diagnosis is very important for timely intervention and improving the survival rate of patients because of its significant morbidity and mortality.

Case presentation

A 24-year-old young male patient with a history of complicated total arch replacement using elephant trunk technique for acute DeBakey type-1 aortic dissection 6 months before visited our hospital with the chief complaint of persistent fever. Antibiotic treatment in local hospital was ineffective. Echocardiography showed liquid dark area around the aortic graft, and a computerized tomography angiography (CTA) was done for further evaluation of periaortic fluid collection which showed findings to suggest perigraft abscess. The patient underwent surgical debridement of the abscess and was found to have an abscess around the aortic graft which was drained followed by antibiotic treatment. The patient was discharged to his local hospital and recovered well at 2 month follow-up appointment.


This is a very rare case of aortic abscess around the graft that could successfully be managed by graft-conserving surgery, and it emphasizes the significance of early diagnosis of perigraft abscess in patients with aortic dissection surgery.

Peer Review reports


AGI are rare events with an incidence of about 3% [1], and perigraft abscess is dreaded complications following aortic repair surgeries with high mortality rates. Early diagnosis is very important for timely intervention and improving the survival rate of patients because of its significant morbidity and mortality [2]. Here we report a rare case of perigraft abscess 6 months after complex aortic dissection operation.

Case presentation

A 24-year-old young man was admitted to our hospital with chief complaints of high-grade fever more than 1 week. Antibiotic treatment in local hospital was ineffective. He denied a history of hypertension or a family history of cardiac disease. Six months prior to admission, the patient developed acute aortic dissection DeBakey type-1 for which he underwent complex surgery including removing autologous aortic walls of the ascending aorta and arch, David procedure, elephant trunk stenting and dacron graft repair of the total arch.

On admission, his blood pressure was 104/84 mmHg, pulse rate 96 beats per minute, and respiratory rate 19 per minute. He was febrile with temperature of 37.8 °C. There was a swelling in the superior sternum fossa, the skin temperature was higher than that of the surrounding normal skin, and the yellow turbid pus flowed out from the surface breach. Hematological findings included C-reactive protein of 59.8 mg/L (reference range<7 mg/L), hemoglobin of 102 g/L (reference range from 120 to160g/L), white blood cell count of 23.35 G/L (reference range from 4 to 10 G/L). Blood bacterial culture was negative. Transthoracic echocardiography showed (Fig. 1a) an echolucent area consistent with fluid or blood around the ascending aorta conduit graft concerning for perigraft leak or abscess, but the valves were not involved. Liquid dark area was found in the subcutaneous tissue above the sternum with a few flocculent echo (Fig. 1b). Due to the concerning findings, a total aortic arch CTA scan with contrast was ordered and showed that the lesion surrounded the ascending aortic artery, aortic arch and its branches, extending into the level of the C7 vertebral body and going down to the origin of the aortic body (Fig. 1c;1d).

Fig. 1
figure 1

(a) Transthoracic echocardiography revealed liquid dark area and a little thrombus around the artificial blood vessels (yellow arrow); (b) The suprasternal view revealed a liquid area of the abscess (yellow arrow); CT angiography scan (c and d) showed perigraft liquid with low density around the artificial blood vessels (yellow arrow); Intraoperative photographs showed (AAO: ascending aorta; AoA:aortic arch; DAO: descending aorta; LA: left atrium; LCCA: left common carotid artery; LPA: pulmonary artery; LSCA: left subclavian artery; PA: pulmonary artery; RPA: right pulmonary artery)

This case was diagnosed with perigraft abscess and treated surgically. We chose a median sternotomy and saw the abscess cavity when opening the skin of the suprasternal (Fig. 2a). After thoracotomy, the old thrombus was cleared, and then washed repeatedly with active iodine and warm saline. No obvious bleeding was found. On surgical exploration, purulent material was drained from the wall of the aorta around the graft and microbiological cultures were obtained. The graft were normal in shape with a little old thrombus tissue (Fig. 2b). Intraoperatively, it was found that there was a clear demarcation between the graft and the abscess collection, and therefore, a decision was made not to explant the graft. After thoracotomy, the thrombus was cleared, then washed repeatedly with active iodine. Bacterial culture of pus and tissues collected during the surgery was negative. All surveillance culture samples collected perioperatively were also negative. Patient was still continued on intravenous antibiotics (Vancomycin mainly) for 2 weeks from the day after surgery. It based on the empirical use of antimicrobial agents in the treatment of infections. He started to defervesce postoperatively and remained afebrile upon discharge. As of 3 months postoperatively, there has been no recurrence of the infection.

Fig. 2
figure 2

Median sternotomy: (a) Abscess cavity under the suprasternal fossa (yellow arrow), the pus had been cleaned up; (b) the shape of the artificial blood vessel was normal (black arrow), and the pus cavity could be seen around it (yellow arrows). (AoA:aortic arch; DAO: descending aorta)


Due to the rarity of AGI, there was no large number of studies to determine the susceptible factors of the disease, early postoperative infection was largely caused by direct microbial infection, and late infection mostly related to underlying diseases, postoperative internal leakage and thrombosis [3]. It is important to identify infectious pathogens in cases of prosthetic graft infection. The common pathogenic microorganisms were bacteria, especially staphylococcus aureus [4]. Late-onset AGI are usually associated with less virulent organisms such as coagulase-negative Stapylococcus, Cirynebacterium, or Propionibacterium species [5]. The bacterial culture of pus in this case was negative, which may be related to the prolonged antibiotic treatment before the examination.

Early diagnosis of AGI was difficult because of its nonspecific manifestations, and the mortality can be as high as 18% ~ 20% [6]. In 2016, the Britain Management of Aortic Graft Infection Collaboration (MAGIC) proposed the diagnostic criteria for AGI [7]. The preoperative radiology examination of this case met one of the major criteria (perigraft fluid on CT scan 3 months after insertion); the clinical manifestations met two minor criteria (localized clinical features of AGI e.g. erythema, warmth, swelling, purulent discharge, pain; fever≥38°Cwith AGI as most likely cause). Therefore, AGI was diagnosed before operation and the extent of involvement was accurately judged, which provided a reliable basis for clinical intervention in time.

The surgical management of AGI depended on the degree and extent of infection. It was generally believed that if the graft and autologous tissue were still surrounded by healthy autologous tissue, the survival rate was higher if the vascular prosthesis not removed [8, 9]. For this case, the graft was not infected and existing prosthetic grafts could be salvaged, so only debridement was performed and the vascular graft not replaced.

According to an international survey which incorporates 62 reported cases from different international centers of vascular surgery, mortality among operative cases was 16.3% and that among conservative management was 36.4% [10]. With such high mortality rates, it is important to focus on prevention, early detection, and prompt treatment of AGI.


We experienced a possibly very rare case of late perigraft infection with aortic abscess formation around the prosthetic vascular. CTA and echocardiography are diagnostic modality of choice which can reveal perigraft fluid and loss of normal tissue. Debridement and drainage are accepted practice in anyone who does not have contraindications for surgery. If the graft is not infected by the abscess, it may be retained.

Availability of data and materials

Please contact the corresponding author for data on reasonable request.



Aortic graft infection


Computerized tomography angiography


Ascending aorta


Aortic arch


Descending aorta


Left atrium


Left common carotid artery


Pulmonary artery


Left subclavian artery


Pulmonary artery


Right pulmonary artery


  1. Fujii T, Kawasaki M, Katayanagi T, et al. A case of an aortic abscess around the elephant trunk.[J]. Atcs. 2015;21(6):570–3.

    Article  Google Scholar 

  2. Moulakakis KG, Sfyroeras GS, et al. Outcome after preservation of infected abdominal aortic Endografts [J]. J Endovasc Ther. 2014;21(3):448–55.

    Article  Google Scholar 

  3. Raj R, Unnikrishnan D, Jacob A, et al. Periaortic Abscess following DeBakey Type-1 Aortic Dissection Repair with Dacron Graft—Early Diagnosis and Management.[J]. Case Rep Cardiol. 2019.

  4. Cernohorsky P, Reijnen MMPJ, Tielliu IFJ, et al. The relevance of aortic endograft prosthetic infection [J]. J Vasc Surg. 2011;54(2):327–33.

    Article  Google Scholar 

  5. Baddour LM, Bettmann MA, Bolger AF, et al. Nonvalvular cardiovascular device-related infections. Clin Infect Dis. 2004;38:1128–30.

    Article  Google Scholar 

  6. Lyons OTA, Patel AS, Saha P, et al. A 14-year experience with aortic Endograft infection: management and results [J]. Eur J Vasc Endovasc Surg. 2013;46(3):306–13.

    Article  CAS  Google Scholar 

  7. Lyons O, Baguneid M, Barwick T, et al. Diagnosis of aortic graft infection: a case definition by the Management of Aortic Graft Infection Collaboration (MAGIC)[J]. Euro J Vasc Endovasc Surg. 2016;52(6):758–63.

    Article  CAS  Google Scholar 

  8. Shiraev T, Barrett S, Heywood S, et al. Incidence, management, and outcomes of aortic graft infection.[J]. Ann Vasc Surg. 2019;59(1):73–83.

    Article  Google Scholar 

  9. Tossios P, Karatzopoulos A, Tsagakis K, et al. Treatment of infected thoracic aortic prosthetic grafts with the in situ preservation strategy: a review of its history, surgical technique, and results [J]. Heart Lung Circulation. 2014;23(1):24–31.

    Article  Google Scholar 

  10. Fiorani P, Speziale F, Calisti A, et al. Endovascular graft infection: preliminary results of an international enquiry. J Endovasc Ther. 2003;10(5):919–27.

    Article  Google Scholar 

Download references


Not applicable.


1. The study was supported by the National Key R&D Program of China (Grant No.2018YFC0114600).

2. The National Natural Science Foundation of China (Grant No. 81000615).

3. Clinician Research Fund of Huazhong University of Science and Technology (Grant No. 5001530051).

Author information

Authors and Affiliations



LL X drafted the manuscript; S L collected the data; YL Y organized the study. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yali Yang.

Ethics declarations

Ethics approval and consent to participate

The hospital ethics committee approval was granted of this case report.

Consent for publication

Written informed consent of clinical data and image publication was obtained from the patient.

Competing interests

None declare.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xu, L., Lin, S. & Yang, Y. Perigraft abscess after DeBakey type-1 aortic dissection: a case report. J Cardiothorac Surg 15, 94 (2020).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: