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Acute mitral valve regurgitation secondary to papillary muscle rupture due to infective endocarditis

Abstract

Background

Papillary muscle rupture due to infective endocarditis is a rare event and proper management of this condition has not been described in the literature. Our case aims to shed light on treatment strategies for these patients using the current guidelines.

Case presentation

This case presents a 58-year-old male with acute heart failure secondary to papillary muscle rupture. He underwent an en bloc resection of his mitral valve with a bioprosthetic valve replacement. Specimen pathology later showed necrotic papillary muscle due to infective endocarditis. The patient was further treated with antibiotic therapy. He recovered well post-operatively and continued to do well after discharge.

Conclusion

In patients who present with papillary muscle rupture secondary to infective endocarditis, clinical symptoms should drive the treatment strategy. Despite the etiology, early mitral valve surgery remains treatment of choice for patients who have papillary muscle rupture leading to acute heart failure. Culture-guided prolonged antibiotic treatment is vital in this category of patients, especially those who have a prosthetic valve implanted.

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Introduction

The prognosis of infective endocarditis is generally poor. The incidence of infective endocarditis-related hospitalization has increased from 34,488 in 2003 to 54,405 in 2016 [1]. Risk factors associated with infective endocarditis include age over 65, intravenous drug use, structural heart disease, valvular disease, prosthetic valve repair, and previous history of infective endocarditis. In the United States, the mortality rate of infective endocarditis between 1980 and 2014 was 2.4 per 100,000 [2].

Endocarditis can cause structural heart damage. Direct leaflet involvement and damage is usually the cause of valve incompetency in these patients. Rarely, infective endocarditis can also involve valve-supporting structures, such as the papillary muscles. Here, we report an atypical cause of papillary muscle rupture. Due to the rarity of this complication, the management of papillary muscle rupture secondary to infective endocarditis can be challenging, complex, and predicated on clinical judgement.

Case report

A 58-year-old male with a past medical history significant for chronic obstructive pulmonary disease presented with shortness of breath exacerbated by exertion. Additional complaints included fever and productive cough. Vital signs were remarkable for tachycardia and oxygen saturation of 96% on two liters of nasal cannula. On physical examination the patient was in no apparent distress. Rales were heard on chest auscultation and cardiac exam was significant for a 3/6 systolic murmur best heard at the apex. Blood work was significant for elevated white blood cell count. Chest X-ray was consistent with pulmonary edema. Cardiac catheterization revealed non-obstructive coronary artery disease. Transthoracic echocardiogram (TTE) showed severe mitral valve regurgitation with a posteriorly directed eccentric jet, and follow-up transesophageal echocardiogram revealed a flail anterior mitral valve leaflet (AMVL) (Fig. 1).

Fig. 1
figure 1

Mitral valve imaging. Flail anterior mitral valve leaflet is seen on transesophageal echocardiogram (A) with evidence of a posteriorly directed regurgitant jet (blue) on transthoracic echocardiogram (B)

The patient was admitted for medical optimization and planned surgical intervention due to acute heart failure secondary to severe mitral regurgitation. Blood cultures showed Staphylococcus haemolyticus growth. After adequate medical optimization, the patient was taken to the operating room for surgical management of the mitral valve.

The operation was done via a mini right thoracotomy incision made through the fourth intercostal space and cardiopulmonary bypass was achieved via left femoral cannulation. Excellent exposure of the mitral valve was achieved through Sondergaard’s groove. Examination of the mitral valve showed maximal prolapse at the A3 region of the AMVL due to complete detachment of the corresponding papillary muscle. The mitral valve and papillary muscle were resected en bloc and sent for culture and pathology (Fig. 2). The mitral valve was replaced with a 31 mm St. Jude Medical Epic™ bioprosthetic valve (St. Jude Medical, Inc., MN, USA). The patient tolerated the procedure well without complications.

Fig. 2
figure 2

Resected papillary muscle and mitral valve

Culture of the surgical specimen showed S. haemolyticus growth consistent with blood culture drawn during admission. Surgical pathology showed extensive histological inflammation and myocardial necrosis consistent with infective endocarditis (Fig. 3). Infectious disease was consulted and a six-week course of intravenous vancomycin was started.

Fig. 3
figure 3

Histological evaluation of the papillary muscle. Histologic findings revealed myocardial necrosis with histiocytic inflammation (A, B), calcification (C), and valvular tissue with myxoid degeneration (D)

Postoperative course was unremarkable. Repeat cultures after the start of antibiotics therapy did not grow any microorganism. The patient was discharged home on postoperative day eight. At 6-week follow up, he denied any new symptoms of fever or chills. TTE showed a well-functioning bioprosthetic mitral valve and preserved ventricular function (Additional file 1: Table S1).

Discussion

Papillary muscle rupture is classified into three categories: ischemic, non-ischemic, and iatrogenic. The non-ischemic subset involves patients with blunt chest trauma, myxomatous disease, spontaneous rupture, and rarely, infective endocarditis as in our patient. Papillary muscle rupture results in severe mitral regurgitation, regardless of the etiology. Unlike with ischemic causes of papillary rupture, patients with non-ischemic etiology have preserved ventricular function, and thus less burden of cardiogenic shock. Although the operative management of papillary muscle rupture may be similar, the etiology of disease differentiates the timing of surgical intervention and outcome.

The timing of sterilization with antibiotics and surgical intervention depends on symptomatic severity and stability [3]. In patients with acute left-sided valvular regurgitation due to infective endocarditis resulting in heart failure, early surgical intervention prior to antibiotic sterilization is the current guideline recommendation [4, 5]. In patients who receive early surgical intervention, risk of mortality is significantly lower compared to late surgical intervention [6].

Although reimplantation of the ruptured papillary muscle might be technically feasible, it is not viable in this patient population, as most are in cardiogenic shock at the time of operation. Furthermore, the rate of recurrent papillary muscle rupture is higher, especially with necrotic tissue. Importantly, in patients with papillary muscle rupture due to infective etiology, extensive debridement and removal of infective tissue is key to eradicating infection, and thus reimplantation is not a viable intervention.

Thus, these patients are better served with valve replacement. Bioprosthetic and mechanical valves have similar long-term outcomes and risk for endocarditis recurrence [7]. Thus, choice of valve, bioprosthetic or mechanical, is up to patient preference. Many patients prefer bioprostheic valves to avoid lifelong anticoagulation, as in our case.

Choice of antibiotic and duration of treatment is another critical factor in the management of patients with infective endocarditis. Blood or tissue cultures are essential in identifying the microorganism involved and directing therapy. In patients with coagulase-negative Staphylococcus infection, as in our patient, treatment with prosthetic valve replacement and a six-week course of vancomycin therapy is recommended [8]. Repeat blood cultures every 24 to 48 h are necessary to monitor response to antibiotic therapy.

Conclusion

Papillary muscle rupture due to infective endocarditis is a rare clinical event; however, prompt treatment can improve outcome. Early surgical intervention in patients with signs of heart failure is imperative. Antibiotic treatment is also vital for successful therapy and prevention of recurrent endocarditis. Implementing both of these treatment strategies allowed our patient to have an excellent outcome.

Availability of data and materials

Not applicable.

Abbreviations

AMVL:

Anterior mitral valve leaflet

TTE:

Transthoracic echocardiogram

References

  1. Alkhouli M, Alqahtani F, Alhajji M, Berzingi CO, Rizwan Sohail M. Clinical and economic burden of hospitalizations for infective endocarditis in the United States. Mayo Clin Proc. 2020;95(5):858–66. https://doi.org/10.1016/j.mayocp.2019.08.023.

    Article  PubMed  Google Scholar 

  2. Roth GA, Dwyer-Lindgren L, Bertozzi-Villa A, Stubbs RW, Morozoff C, Naghavi M, Mokdad AH, Murray CJL. Trends and patterns of geographic variation in cardiovascular mortality among US counties, 1980–2014. JAMA. 2017;317(19):1976–92. https://doi.org/10.1001/jama.2017.4150.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Tleyjeh IM, Rybak MJ, Barsic B, Lockhart PB, Gewitz MH, Levison ME, Bolger AF, Steckelberg JM, Baltimore RS, Fink AM, O'Gara P, Taubert KA. American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2015;132(15):1435–86. https://doi.org/10.1161/CIR.0000000000000296. Epub 2015 Sep 15. Erratum in: Circulation. 2015 Oct 27;132(17):e215. Erratum in: Circulation. 2016 Aug 23;134(8):e113. Erratum in: Circulation. 2018;138(5):e78–9.

  4. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Fleisher LA, Jneid H, Mack MJ, McLeod CJ, O’Gara PT, Rigolin VH, Sundt TM 3rd, Thompson A. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. J Am Coll Cardiol. 2017;70(2):252–89. https://doi.org/10.1016/j.jacc.2017.03.011.

    Article  PubMed  Google Scholar 

  5. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Muñoz D, Rosenhek R, Sjögren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL, ESC Scientific Document Group. ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2017;38(36):2739–91. https://doi.org/10.1093/eurheartj/ehx391.

    Article  PubMed  Google Scholar 

  6. Anantha Narayanan M, Mahfood Haddad T, Kalil AC, Kanmanthareddy A, Suri RM, Mansour G, Destache CJ, Baskaran J, Mooss AN, Wichman T, Morrow L, Vivekanandan R. Early versus late surgical intervention or medical management for infective endocarditis: a systematic review and meta-analysis. Heart. 2016;102(12):950–7. https://doi.org/10.1136/heartjnl-2015-308589.

    Article  PubMed  Google Scholar 

  7. Toyoda N, Itagaki S, Tannous H, Egorova NN, Chikwe J. Bioprosthetic versus mechanical valve replacement for infective endocarditis: focus on recurrence rates. Ann Thorac Surg. 2018;106(1):99–106. https://doi.org/10.1016/j.athoracsur.2017.12.046.

    Article  PubMed  Google Scholar 

  8. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL, Task Force per il Trattamento dell'Endocardite Infettiva della Società Europea di Cardiologia (ESC). 2015 ESC guidelines for the management of infective endocarditis. The task force for the management of infective endocarditis of the European Society of Cardiology (ESC). G Ital Cardiol (Rome). 2016;17(4):277–319.

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Acknowledgements

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Funding

The authors report no forms of financial support in the production of this case report. Farshad Amirkhosravi is a Burroughs Wellcome Fund Fellow supported by a Burroughs Wellcome Fund Physician Scientist Institutional Award to the Texas A&M University Academy of Physician Scientists.

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FA: Conception, design, analysis and drafting of the manuscript and critical revisions and final approval of the manuscript. QA: Review of the manuscript and final approval of the manuscript. AL: Review of the manuscript and final approval of the manuscript. LE: Review of the manuscript and final approval of the manuscript. RE: Review of the manuscript and final approval of the manuscript. MW: Review of the manuscript and final approval of the manuscript. MR: Conception, design, analysis and interpretation of case and clinical management. Drafting of the manuscript and critical revisions and final approval of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mahesh K. Ramchandani.

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Supplementary Information

Additional file 1. Table S1:

Timeline of the patient’s course of illness.

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Amirkhosravi, F., Al Abri, Q., Lu, A.J. et al. Acute mitral valve regurgitation secondary to papillary muscle rupture due to infective endocarditis. J Cardiothorac Surg 17, 173 (2022). https://doi.org/10.1186/s13019-022-01854-2

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Keywords

  • Papillary muscle rupture
  • Infective endocarditis
  • Mitral regurgitation
  • Case report