Skip to main content

Refractory post-thymectomy myasthenia gravis with onset at MGFA stage V: a case report

Abstract

Background

Post-thymectomy myasthenia gravis (PTMG) is defined as thymoma patients without signs of myasthenia gravis (MG) pre-operation, but develop MG after radical surgical resection. PTMG might be misdiagnosed not only because of its rare incidence, but also the uncertain interval between the removal of thymoma and the new onset MG. Additionally, some surgeons and anesthesiologists pay less attention to those asymptomatic thymoma patients in perioperative management, leading to the neglect of new onset PTMG, and miss the best time to treat it.

Case presentation

Majority of cases of PTMG with onset at stage I–II on the basis of Myasthenia Gravis Foundation of America (MGFA) classification have been reported, but rarely at stage V, which requiring intubation or non-invasive ventilation to avoid intubation. Herein, we presented a 70-year-old male with PTMG onset at MGFA stage V, meanwhile, he had severe pulmonary infection interfering with the diagnosis of PTMG, and eventually progressed to refractory PTMG, which requiring much more expensive treatments and longer hospital stays.

Conclusion

In the perioperative management of asymptomatic thymoma patients, careful preoperative evaluation including physical examination, electrophysiological test and acetylcholine receptor antibodies (AChR-Ab) level should be done to identify subclinical MG. Complete resection should be performed during thymectomy, if not, additional postoperative adjuvant therapy is neccessary to avoid recurrence. It’s important to identify PTMG at a early stage, especially when being interfered with by postoperative complications, such as lung infection, so that treatments could be initiated as soon as possible to avoid developing to refractory PTMG.

Peer Review reports

Background

Post-thymectomy myasthenia gravis (PTMG) is that thymoma patients who have no signs of MG before surgery, but develop myasthenia gravis (MG) after radical surgical resection. PTMG might be misdiagnosed not only because of its rare incidence, 0.97–13.39% in previous studies [1,2,3,4,5,6,7,8], but also the uncertain interval between the removal of thymoma and the new onset of PTMG, ranged from 3 days to over 14 years [3, 7]. There have been reported majority of cases of post-thymectomy MG with onset at stage I-II on the basis of Myasthenia Gravis Foundation of America (MGFA) classification, but rarely at stage V, which requiring intubation or non-invasive ventilation to avoid intubation [9]. We present the patient of PTMG with onset at MGFA stage V, meanwhile, he had severe lung infection, which interfering with the diagnosis, and unfortunately he eventually developed to refractory PTMG.

Case report

A 70-year-old male was hospitalized with intermittent chest pain. He had no background diseases and his physical examination was unremarkable. The computed tomographic (CT) scan showed an anterosuperior mediastinal mass surrounded large blood vessels, and positron emission tomographic (PET) scan revealed no evidence of a metastatic tumor. The thoracic CT angiography showed the shape of the vessel wall was still regular, and there was no obvious sign of filling defect. Thymoma was the most likely diagnosis and could be directly surgically resected post discussion and evaluation by our multidisciplinary team. As the patient had no signs of MG at that time, anti-AChR antibodies test and electromyogram were not performed. His lung function was normal. In April 2020, he received a median sternotomy, thymothymectomy, pericardiectomy and left upper lobectomy were performed to ensure a complete resection. Histology of the tumor showed a thymoma type B2 (WHO classification), Masaoka stage III. 9 days later, he was discharged without any postoperative complications. However, 14 Days after the surgery, he complained of dyspnea and fever, thoracic CT showed no evidence of tumor reccurence, but increased patchy density was seen in both lower lungs. He had a sudden loss of consciousness in the emergency room, and the blood gas analysis showed a type II respiratory failure with the level of partial pressure of carbon dioxide over 100 mmHg, endotracheal intubation and ventilator assisted ventilation were performed immediately. Severe pneumonia was diagnosed according to the clinical outcome, confirmed by the result of bacterial culture of bronchoalveolar lavage fluid, acinetobacter baumannii. With sensitive antibiotics treatment, the lung infection was controlled and his condition was markedly improved. However, we failed to wean him off ventilation. Neostigmine test was negative in this patient, but repetitive nerve stimulation test was positive and the titer of anti-AChR antibody was slightly elevated, at 0.43 nmol/L (cut-off value for positive: > 0.5 nmol/L, questionable positive: 0.4–0.5 nmol/L, negative: < 0.4 nmol/L), the neurologist suggested that PTMG should be taken into consideration, as patients with MG often require prolonged ventilatory support, we did tracheostomy to facilitate his weaning of the ventilator on day 10 after endotracheal intubation. With the administration of pyridostigmine bromide (180 mg/d), he could gradually wean off the ventilator. Nevertheless, he suffered form refractory diarrhea, a serious side effect of pyridostigmine bromide, then we discontinued the medications, leading to his ventilation requirement again, therewith, he was referred to neurology care unit for specialist treatment. Intravenous immunoglobulin (IVIG) was suggested as an optimal treatment, but was refused for its high cost at first. Steroid pulse therapy was initiated instead, unfortunately the effect was slow and poor, so plasmapheresis and IVIG were administrated successively. At 4 months after his admission, he was eventually removed from the ventilator with a low dose tacrolimus of 1 mg/day.

Discussion

Myasthenia gravis (MG) is caused by an autoimmune antibody against acetylcholine receptors on the neuromuscular junction, which usually coexists with thymoma. The incidence of thymoma in MG is about 10%-12%, and that of MG in thymoma is approximately 30% [4, 6, 10]. Complete resection is the gold standard for treating thymoma. The complete remission rate after thymectomy in preoperative MG patients was 44.1–59.5% according to previous studies [11,12,13]. However, asymptomatic thymoma patients can develop PTMG. The mechanism of the onset of PTMG is unclear. Risk factors include a positive result for serum AChR-Ab, incomplete resection, and postoperative infection [7].

Some studies supported that elevated level of preoperative AChR-Ab could be proof of an subclinical MG [5, 6, 8]. Ito et al. divided their patients with PTMG into early and late onset group respectively, and found the early onset group may have had subclinical MG when they underwent initial surgery [2]. Previous studies revealed the incidence of PTMG in preoperative AchR-Ab positive patients were 23, 18.75 and 30.3%, respectively, and those of PTMG in preoperative AchR-Ab negative patients were 4.76, 2.78 and 0%, respectively [5, 7, 8], which suggested that preoperative high level of AchR-Ab might be a predictive indicator for the development of PTMG. In our case, there was a limitation that the patient’s preoperative Ach-Ab serum level and electromyogram weren’t measured. Although the postoperative serum titer of AChR-Ab was just slightly elevated, the clinical symptoms of PTMG were quite serious, which indicated that AChR-Ab level had a poor correlation with the clinical severity of MG patient [14].

In the late onset group of Ito’s study, they found PTMG was associated with tumor recurrence [2]. Mineo et al. redid surgeries to remove residual fat tissue where increased metabolic activity were detected in the late onset PTMG patients, resulting in complete remission [8]. However, in our case, the patient wasn’t found any evidence of recurrence, Kondo et al. also didn’t find any amelioration in PTMG patients after the resection of the residual thymus gland, which indicated extrathymic mechanism may play a role in the production of AchR-Ab [4]. Studies found mature autoantigen-specific T cells coming from thymomas could persist in the peripheral blood for many years [9, 15].

In our case, we blamed the patient’s respiratory failure on the severe pneumonia initially, without awareness of coexisting PTMG. Actually, pneumonia is a common complication after thoracic surgeries, mainly attributed to the stagnation of airway secretion, which can be also caused by respiratory muscle weakness in MG patients. Infection can not only induce MG, but also lead to MG deterioration [16]. As seen in our case, his severe pneumonia may be the result of MG, which in turn leads to MG deterioration, forming a vicious cycle. Combined with our unwareness of new onset PTMG, the patient missed the best opportunity for treatment, and finally developed to refractory PTMG, requiring much more expensive treatments and longer hospital stays.

Conclusion

In the perioperative management of asymptomatic thymoma patients, careful evaluation including physical examination, electrophysiological test and AChR-Ab level should be done to identify subclinical MG, so that the surgeons and anesthesiologists could take measures in advance to avoid PTMG. Complete resection should be performed during thymectomy, if not, additional postoperative adjuvant therapy is neccessary to avoid recurrence. It’s important to identify PTMG at a early stage, especially when being interfered with by postoperative complications, such as lung infection, so that treatments could be initiated as soon as possible to avoid developing to refractory PTMG.

Availability of data and materials

Not applicable.

Abbreviations

PTMG:

Post-thymectomy myasthenia gravis

MG:

Myasthenia gravis

MGFA:

Myasthenia Gravis Foundation of America

AChR-Ab:

Acetylcholine receptor antibodies

CT:

Computed tomography

PET:

Positron emission tomography

anti-AChR:

Anti-acetylcholine receptor

References

  1. Namba T, Brunner NG, Grob D. Myasthenia gravis in patients with thymoma, with particular reference to onset after thymectomy. Medicine. 1978;57(5):411–33.

    Article  CAS  Google Scholar 

  2. Ito M, Fujimura S, Monden Y, et al. A retrospective group study on post-thymectomy myasthenia gravis. Nihon Kyobu Geka Gakkai. 1992;40(2):189–93 ((In Japanese)).

    CAS  Google Scholar 

  3. Li J, Zhang DC, Wang LJ, Zhang DW, Zhang RG. Myasthenia gravis occurring after resection of thymoma. Chin J Surg. 2004;42(9):540–2 ((In Chinese)).

    PubMed  Google Scholar 

  4. Kondo K, Monden Y. Myasthenia gravis appearing after thymectomy for thymoma. Eur J Cardiothorac Surg. 2005;28(1):22–5.

    Article  Google Scholar 

  5. Nakajima J, Murakawa T, Fukami T, Sano A, Takamoto S, Ohtsu H. Postthymectomy myasthenia gravis: relationship with thymoma and antiacetylcholine receptor antibody. Ann Thorac Surg. 2008;86(3):941–5.

    Article  Google Scholar 

  6. Sun XG, Wang YL, Liu YH, Zhang N, Yin XL, Zhang WJ. Myasthenia gravis appearing after thymectomy. J Clin Neurosci. 2011;18(1):57–60.

    Article  CAS  Google Scholar 

  7. Yamada Y, Yoshida S, Iwata T, et al. Risk factors for developing postthymectomy myasthenia gravis in thymoma patients. Ann Thorac Surg. 2015;99(3):1013–9.

    Article  Google Scholar 

  8. Mineo TC, Tamburrini A, Schillaci O, Ambrogi V. Onset and evolution of clinically apparent myasthenia gravis after resection of non-myasthenic thymomas. Semin Thorac Cardiovasc Surg. 2018;30(2):222–7.

    Article  Google Scholar 

  9. Sanders DB, Wolfe GI, Benatar M, et al. International consensus guidance for management of myasthenia gravis: executive summary. Neurology. 2016;87(4):419–25.

    Article  Google Scholar 

  10. Thomas CR, Wright CD, Loehrer PJ. Thymoma: state of the art. J Clin Oncol: Off J Am Soc Clin Oncol. 1999;17(7):2280–9.

    Article  CAS  Google Scholar 

  11. Kaufman AJ, Palatt J, Sivak M, et al. Thymectomy for myasthenia gravis: complete stable remission and associated prognostic factors in over 1000 cases. Semin Thorac Cardiovasc Surg. 2016;28(2):561–8.

    Article  Google Scholar 

  12. Yang J, Liu C, Li T, Li C. Prognosis of thymectomy in myasthenia gravis patients with thymus hyperplasia. Int J Neurosci. 2017;127(9):785–9.

    Article  Google Scholar 

  13. Tian W, Li X, Tong H, et al. Surgical effect and prognostic factors of myasthenia gravis with thymomas. Thoracic Cancer. 2020;11(5):1288–96.

    Article  Google Scholar 

  14. Sanders DB, Burns TM, Cutter GR, Massey JM, Juel VC, Hobson-Webb L. Does change in acetylcholine receptor antibody level correlate with clinical change in myasthenia gravis? Muscle Nerve. 2014;49(4):483–6.

    Article  CAS  Google Scholar 

  15. Hoffacker V, Schultz A, Tiesinga JJ, et al. Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. Blood. 2000;96(12):3872–9.

    Article  CAS  Google Scholar 

  16. Gilhus NE, Romi F, Hong Y, Skeie GO. Myasthenia gravis and infectious disease. J Neurol. 2018;265(6):1251–8.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We are grateful for all the help given to us

Funding

None.

Author information

Authors and Affiliations

Authors

Contributions

R-QZ, L-JL participated to the care of the patient. R-QZ, Q-CW participated in the design of the study and draft the manuscript. All authors read and approved the final submission.

Corresponding author

Correspondence to Qing-Chen Wu.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Informed consent for publication was obtained.

Competing interests

The authors declare that they have no competing interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, RQ., Li, LJ. & Wu, QC. Refractory post-thymectomy myasthenia gravis with onset at MGFA stage V: a case report. J Cardiothorac Surg 17, 115 (2022). https://doi.org/10.1186/s13019-022-01872-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s13019-022-01872-0

Keywords