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Table 2 Logistic regression analysis

From: Analysis of influencing factors of perioperative myasthenic crisis in 387 myasthenia gravis patients without thymoma in a single center

Variables

Univariate analysis

Multivariate analysis

OR

95% CI

P value

OR

95% CI

P value

Gender

 Female

Reference

  

 Male

1.029

0.552–1.918

0.929

   

Age

1.024

1.004–1.045

0.020

0.989

0.956–1.024

0.536

Other autoimmune disorders

0.780

0.265–2.300

0.653

   

Preoperative history of myasthenic crisis

21.250

3.991–113.136

0.000

19.823

1.892–207.705

0.013

Preoperative course

  < 12 months

Reference

Reference

  ≥ 12 months

1.564

0.839–2.917

0.159

   

Osserman classification

 I + IIA

Reference

Reference

 IIB + III + IV

37.798

9.002–158.709

0.000

29.575

5.981–146.237

0.000

Preoperative daily dose of pyridostigmine bromide

  ≤ 240 mg

Reference

Reference

  > 240 mg

6.816

3.534–13.147

0.000

6.897

2.544–18.693

0.000

Preoperative immunosuppressants

1.042

0.417–2.604

0.930

   

Preoperative steroid

1.835

0.825–4.085

0.137

   

ASA score

 1

Reference

Reference

 2 + 3

3.279

1.638–6.564

0.001

8.884

2.526–31.246

0.001

FEV1

0.327

0.189–0.566

0.000

0.506

0.152–1.679

0.266

FEV1/FVC

0.988

0.951–1.026

0.531

   

FEV1%

0.971

0.954–0.988

0.001

0.995

0.961–1.030

0.767

MVV%

0.983

0.966–1.000

0.046

1.006

0.985–1.028

0.557

DLCO%

0.980

0.963–0.998

0.033

0.980

0.957–1.005

0.116

Operation time

1.005

0.998–1.012

0.153

   

Surgical procedure

 OT

Reference

Reference

 VAST

1.293

0.427–3.912

0.650

   

Blood loss

 0–1000

Reference

Reference

  > 1000

7.907

1.086–57.582

0.041

27.550

0.926–819.913

0.055

Drainage volume over the first three days

 0–800

Reference

  

  > 800

1.191

0.607–2.338

0.611

   

Ectopic thymus

0.749

0.169–3.316

0.703

   

Preoperative application of gamma globulin

5.909

2.720–12.839

0.000

1.179

0.393–3.531

0.769

  1. Bold value indicates the P-value is lower than 0.05
  2. FEV1 Forced expiratory volume in 1 s, FVC Forced vital capacity, MVV Maximal voluntary ventilation, DLCO Diffusion lung capacity for carbon monoxide, OT Open thoracotomy, VAST Video-assisted thoracic surgery