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Table 2 Univariable and multivariable analyses of DFS and OS

From: Influence of adjuvant chemotherapy on survival for patients with completely resected high-risk stage IB NSCLC

Variable

Univariable analyses

Multivariable analyses

HR

95%CI

P value

HR

95%CI

P value

disease-free survival (DFS)

Age

1.036

0.998 ~ 1.075

0.066

1.001

0.959 ~ 1.045

0.967

Male sex

1.326

0.705 ~ 2.491

0.381

0.936

0.427 ~ 2.055

0.87

ACI-PAP

      

LEP

1.271

0.2596.243

0.767

1.025

0.201 ~ 5.232

0.976

MIP-SOL

12.714

5.188 ~ 31.161

< 0.001***

17.178

6.164 ~ 47.876

< 0.001***

Poor differentiated SCC

18.827

6.453 ~ 54.928

< 0.001***

18.194

5.485 ~ 60.351

< 0.001***

Moderate/high differentiated SCC

3.708

0.903 ~ 15.230

0.069

2.757

0.616 ~ 12.334

0.185

Mixed

4.944

0.914 ~ 26.743

0.063

2.694

0.418 ~ 17.360

0.297

Number of resected lymph nodes < 16

0.943

0.900 ~ 0.988

0.013*

0.904

0.851 ~ 0.961

< 0.001***

Tumor diameter(mm)

1.222

1.108 ~ 1.348

< 0.001***

1.237

1.0981.394

< 0.001***

Visceral pleural invasion

1.851

0.989 ~ 3.465

0.054

2.340

1.0635.155

0.035*

ACT

0.932

0.475 ~ 1.831

0.838

0.568

0.249 ~ 1.296

0.179

Overall survival (OS)

Age

1.071

0.994 ~ 1.153

0.072

1.061

0.975 ~ 1.155

0.172

Male sex

1.833

0.541 ~ 6.210

0.330

1.315

0.306 ~ 5.657

0.713

ACI-PAP

      

LEP

< 0.001

< 0.001

0.998

< 0.001

< 0.001

0.998

MIP-SOL

5.571

1.513 ~ 20.523

0.010*

4.872

1.087 ~ 21.836

0.039*

Poor differentiated SCC

4.136

0.716 ~ 23.901

0.113

2.864

0.391 ~ 20.999

0.0301*

Moderate/high differentiated SCC

< 0.001

< 0.001

0.998

< 0.001

< 0.001

0.998

Mixed

< 0.001

< 0.001

0.999

< 0.001

< 0.001

0.999

Number of resected lymph nodes < 16

1.065

0.972 ~ 1.167

0.177

1.061

0.967 ~ 1.163

0.209

Tumor diameter(mm)

1.301

1.073 ~ 1.577

0.008**

1.355

1.096 ~ 1.676

0.005**

Visceral pleural invasion

3.552

1.047 ~ 12.050

0.042*

5.065

1.266 ~ 20.259

0.022*

ACT

1.563

0.484 ~ 5.044

0.455

1.176

0.296 ~ 4.666

0.818

  1. HR, hazard ratio; CI, confidence interval