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Progressive cyanosis following Kawashima operation: slow resolution after redirection of hepatic veins
© Larsen et al.; licensee BioMed Central Ltd. 2013
Received: 30 January 2013
Accepted: 21 March 2013
Published: 5 April 2013
Progressive cyanosis often develops following Kawashima operation in patients with left atrial isomerism, interrupted inferior vena cava and hepatic veins draining to the atria. Knowledge on the timing and extend of resolution following hepatic venous redirection is sparse. A girl developed progressing cyanosis following Kawashima operation at the age of ten months. Arterial oxygen saturations at rest dropped to 60-65%. Surgical redirection of hepatic veins into the cavopulmonary circulation at the age of three years had no immediate effect. However, arterial oxygen saturations increased gradually over nine months to 90-93% and 95-100% after three years.
KeywordsCongenital heart surgery Pulmonary arteriovenous malformations Fontan Left atrial isomerism
Patients with functional univentricular hearts, left atrial isomerism and azygos continuation of the inferior vena cava are usually surgically palliated by cavopulmonary anastomosis between one or two superior vena cavas to the pulmonary artery, the Kawashima operation. The hepatic veins remain connected to one or both left atria and thus to the systemic circulation, which in itself will cause some arterial desaturation. However, in many patients arterial desaturation is progressive causing cyanosis and functional limitation. When veno-venous collaterals from the systemic to the hepatic veins are excluded, progressive cyanosis is attributed to development of multiple microscopic pulmonary arteriovenous malformations [1, 2]. It is hypothesized that one or more unknown hepatic factors from the hepatic circulation need to flow directly to the pulmonary circulation in order to suppress a genuine tendency to develop arteriovenous malformations in the lungs [3, 4]. A recent study  suggests that inhibition of endostatin may play an important role in increased angiogenesis and formation of arteriovenous malformations. Several reports [6–9] indicate that cyanosis resolves following surgical redirection of hepatic veins into the cavopulmonary circulation. This operation is usually performed through a median sternotomy using cardiopulmonary bypass. However, an off-pump technique through a lateral thoracotomy has been described . The literature on the timing and extent of resolution following redirection of the hepatic veins is sparse.
In order to demonstrate this may be a lengthy process, we report our experience of redirecting hepatic flow in a patient with left atrial isomerism and review the current literature.
A newborn girl was diagnosed with dextrocardia, left atrial isomerism, azygous continuation to a solitary left sided superior vena cava, hepatic veins draining to the left sided atrium, unbalanced atrioventricular septal defect, double outlet right ventricle and valvar pulmonary stenosis. Initially the patient was surgically palliated with an aortopulmonary shunt. Kawashima operation with closure of the shunt was performed at the age of ten months. Postoperatively resting saturations were initially 85-90%, but declined over the next two years to 60-65%. Cardiac catheterization showed an unobstructed left-sided cavopulmonary anastomosis, low pulmonary artery pressures and absence of significant veno-venous collaterals. No macroscopic arteriovenous malformations were present. At the age of three years, the hepatic veins were excised from the atrium with a cuff of atrial tissue, anastomosed to a GORE-TEX® tube graft which was placed along the left side of the heart and anastomosed end-to-side to the confluent pulmonary arteries facing the superior cavopulmonary connection. The operation was done through a median sternotomy using cardiopulmonary bypass on beating heart. Postoperatively oxygen saturations were initially 60-70% but increased to approximately 85% after four weeks, 90-93% after nine months and 95-100% after three years, when she was last seen.
Summary of the current literature of arterial oxygen saturations following redirection of hepatic venous flow in Kawashima patients
Time from Kawashima to diagnosis/ redirection of PAVMs
Saturation at diagnosis
Saturation at early follow-up (follow-up time)
Saturation at last follow-up (follow-up time)
70% at discharge
85% (1 year)
92% (6 months)
5.7±3.1 years (2-11)†
95±2% (93-98)† (4.1±2.3 years (1-7))†
96% (13 months)
2.61 years (0.61-7.35)‡
80% (day of operation)
>93% (2 years)
3.1 years (6 months-10 years)‡
76±8% (1 week-12 months)†§
90±9%† (6.3 years (2.8-10 years))‡
85% ||(48 hours)
75% (4th day), 85% (3 weeks)
94% (7 weeks), 93-94% (7 months)
8 months (7-27)‡
Range 80-84% (7-10 days)
>92% (7-12 months)
5 years and 9 months
70% (1 month), 80 (0.5 years)
90% (2 years)
The development and diagnosis of pulmonary arteriovenous malformations following the Kawashima operation usually takes several years [4, 6, 9, 13, 15–20], but has been described after a few days . Pulmonary arteriovenous malformations are usually diagnosed when oxygen saturations are between 65 and 76% [4, 9, 13, 15–18].
Most studies report that pulmonary arteriovenous malformations resolve slowly following surgical redirection of the hepatic flow. Resting oxygen saturations as low as 70-85% for months after the operation are common [4, 6, 13, 15, 17, 18]. In general, the saturations improve over time. Studies with a follow-up of several months to a few years report saturations between 93 and 97% [8, 9, 15, 17, 18, 20, 22]. Saturations remaining at 85-90% have been described [4, 13]. Timing of redirection of hepatic flow remains controversial. A recent study  indicates that the majority of patients will need redirection of hepatic flow following the Kawashima operation, in particular when followed beyond 60 months. Furthermore, there was an indication that worse outcome was related to profound desaturation before redirection, indicating a benefit of an earlier redirection .
In patients with left atrial isomerism pulmonary arteriovenous malformations should be considered when the hepatic flow has not been included in the TCPC and saturations start to decline. Following surgical inclusion of hepatic veins recovery may take several months to occur.
Written informed consent was obtained from the family of patient for publication of this Case report. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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