Skip to main content

Trapezoidal resection of an elongated anterior mitral leaflet and Alfieri stitch in hypertrophic cardiomyopathy

Abstract

Background

In individuals with hypertrophic obstructive cardiomyopathy, elongated anterior mitral leaflets are commonly associated with systolic anterior motion. In patients with mild septal hypertrophy, a myectomy is considered insufficient to relieve systolic anterior motion and left ventricular outflow tract obstruction.

Case presentation

In the patient, who had relatively mild septal hypertrophy, the section of the anterior leaflet protruding into the left ventricular outflow tract was resected, concomitant with septal myectomy and the relocation of the papillary muscles. An edge-to-edge stitch was placed at the uppermost segment of the coaptation zone. Using these manoeuvres, systolic anterior motion, left ventricular outflow tract obstruction and mitral regurgitation were successfully resolved postoperatively.

Conclusions

We describe a surgical technique with an edge-to-edge suture for the resection of an elongated anterior mitral leaflet. In combination with septal myectomy and relocation of the papillary muscles, this technique is a simple and viable option, especially when septal hypertrophy is not severe.

Peer Review reports

Background

Structural mitral valve abnormalities are frequently observed in individuals with hypertrophic cardiomyopathy. Redundant or elongated anterior mitral leaflets are commonly associated with systolic anterior motion (SAM). Here, we describe a simple surgical technique for the removal of an elongated anterior mitral leaflet.

Case presentation

A 76-year-old woman with exertional dyspnoea was referred to our hospital. Echocardiography revealed the presence of SAM and severe mitral regurgitation (MR). The left ventricular diastolic dimension and ejection fraction were 39 mm and 81%, respectively. The elongated A2 segment contacted the septum at systole, causing left ventricular outflow tract obstruction (LVOTO) (Fig. 1, top). Although oral medication was administered, the left ventricular outflow tract (LVOT) gradient was determined to be 127 mmHg. Septal hypertrophy was relatively mild. The maximum thickness of the septum beneath the aortic annulus was 17 mm. The pressure gradient of tricuspid regurgitation was 21 mmHg. The functional status was classified as New York Heart Association class II. Significant stenosis was not observed in the coronary or carotid arteries. The patient did not have a history of syncope or ventricular arrhythmia. Cardiac magnetic resonance imaging revealed that the papillary muscle tips had deviated anomalously to the anterior or septal walls due to the attachment of fibrous or muscular tissues between the septum and the papillary muscles (Fig. 2). Although septal ablation was considered, a reduction in the septal thickness alone was deemed to be insufficient to relieve SAM. Taking the case of severe LVOTO and the risk of sudden death into account, we decided to first perform surgical repair.

Fig. 1
figure1

(Top) Preoperative transthoracic echocardiography revealed a left ventricular outflow obstruction caused by systolic anterior motion of the anterior mitral leaflet. The septal thickness was 17 mm at the contact point. (Lower) Postoperatively, echocardiography showed the absence of systolic anterior motion and mitral regurgitation. Accelerated flow in the left ventricular outflow tract was not detected

Fig. 2
figure2

Cardiac magnetic resonance imaging in late systole. In this patient, two mechanisms of SAM were postulated. One was that the tips of papillary muscles anomalously deviated anteriorly. The papillary muscles were connected with the septum with abnormal fibrous tissue and touching the septum in systole. The other mechanism involves the elongated anterior leaflet. It was turned over by the blood flow through LVOT, as described by Schwammenthal et al. [1]

Through a right-sided left atriotomy, the mitral valve was inspected. Thickened secondary chordae and muscular bundles connecting the papillary muscles and the anterior or septal wall were divided. Both papillary muscles were repositioned posteriorly by fixing the secondary papillary muscle with 4–0 expanded polytetrafluoroethylene (ePTFE) mattress sutures. The competency of the mitral valve was then confirmed (Fig. 3, top). The A2 segment was thickened and anomalously elongated and was considered the cause of the SAM (Fig. 3, middle). A 5–0 ePTFE horizontal mattress suture was placed at the uppermost segment of the coaptation zone. Before the suture was tied, a trapezoidal portion of the elongated leaflet below the ePTFE stitch and the attached chordae were resected (12 × 12 mm) (Fig. 3, bottom). Subsequently, a 6 × 6 mm trapezoidal section of the posterior leaflet below the suture was resected. Finally, the edge-to-edge ePTFE suture was tied.

Fig. 3
figure3

After subvalvular manoeuvres, the coaptation of A2 and P2 was evaluated using a blue marker (top). A 5–0 expanded polytetrafluoroethylene horizontal mattress suture was placed, with the elongated portion of the anterior leaflet below the stitch (middle). The segment (solid line) with the attached chorda was resected (middle and bottom). Finally, the ePTFE stitch was tied, and the mitral valve remained competent

Transverse aortotomy was performed just above the sinotubular junction. Myectomy was performed through the aortic valve. Due to mild hypertrophy, myectomy was performed carefully in a section measuring approximately 10 mm in width and < 5 mm in thickness.

After the patient was weaned from cardiopulmonary bypass, transoesophageal echocardiography revealed the absence of accelerated flow and MR; the next morning, she was extubated. The postoperative course was uneventful. Transthoracic echocardiography revealed that LVOTO, MR and SAM were not detected (Fig. 1, bottom). The patient was discharged from the hospital on postoperative day 12. The symptoms disappeared, and there were no ventricular arrhythmia or cardiac events postoperatively. The automated implantable cardioverter defibrillator has not yet been implanted. At 2.5 years after the operation, with echocardiography, SAM was not seen. Trivial mitral regurgitation was detected, and the peak pressure gradient through LVOT was calculated to be 14 mmHg.

The resection of the anterior mitral leaflet and the placement of an edge-to-edge stitch, concomitant with septal myectomy and the relocation of papillary muscles, were performed in four patients (Table 1). In one patient (case 5), the manoeuvres were only performed on the anterior leaflet to treat SAM associated with mitral valve repair. In all cases, SAM, MR and LVOTO were successfully resolved. In one patient (case 4) with a small left ventricle and a diastolic dimension of 30 mm, a new accelerated flow at the mid-ventricle was detected, probably due to the Venturi effect.

Table 1 Procedures performed and echocardiographic data

Discussion and conclusion

Operative techniques for hypertrophic obstructive cardiomyopathy usually consist of a manoeuvre or a combination of manoeuvres involving the septum, the mitral leaflet and the subvalvular apparatus. When septal hypertrophy is relatively mild, manoeuvres involving the leaflet and the subvalvular apparatus may be crucial. Regarding the manoeuvre involving the leaflet, when the anterior leaflet is elongated by more than 30 mm, plication can shorten the leaflet length by 2–5 mm [2, 3]. The edge-to-edge technique is an option for manoeuvring the mitral leaflet [4, 5]. Currently, this procedure can also be performed on a beating heart [6]. Regarding the manoeuvre on the subvalvular apparatus, chordal cutting was reported to be effective for LVOTO relief through geometric modifications [7]. Moreover, Balaram and colleagues performed a combination of septal myectomy, the release of papillary muscles, and plication of the anterior leaflet [3]. Our technique was a modification of this combination.

Since our patient had relatively mild septal hypertrophy, the abnormal subvalvular apparatus and elongated anterior leaflet played definitive roles in the manifestation of SAM [1]. The papillary muscles were freed from the septal or anterior walls and relocated posteriorly. With our technique involving the mitral leaflet, trapezoidal resection of the elongated anterior leaflet is crucial. The segment of the anterior leaflet that protruded into the LVOT was resected with the chordae. The elongated posterior leaflet was resected in the same manner. After resection, an edge-to-edge suture was essential to maintain valve competence because the coaptation zone became minimal and did not have any chordae attached. The follow-up echocardiography findings revealed that SAM, LVOTO and MR had been successfully resolved for 2.5 years.

In conclusion, resection of the anterior mitral leaflet that causes SAM concomitant with the placement of an edge-to-edge suture is a viable option for treating the leaflet, especially when ventricular hypertrophy is not severe.

Availability of data and materials

The datasets used or analysed during the current study are available from the corresponding author, on reasonable request.

Abbreviations

ePTFE:

Expanded polytetrafluoroethylene

LVOT:

Left ventricular outflow tract

LVOTO:

Left ventricular outflow tract obstruction

MR:

Mitral regurgitation

SAM:

Systolic anterior motion

References

  1. 1.

    Schwammenthal E, Nakatani S, He S, Hopmeyer J, Sagie A, Weyman AE, et al. Mechanism of mitral regurgitation in hypertrophic cardiomyopathy mismatch of posterior to anterior leaflet length and mobility. Circulation. 1998;98:856–65.

    CAS  Article  Google Scholar 

  2. 2.

    Balaram SK, Ross RE, Sherrid MV, Schwartz GS, Hillel Z, Winson G, et al. Role of mitral valve plication in the surgical management of hypertrophic cardiomyopathy. Ann Thorac Surg. 2012;94(6):1990–7.

    Article  Google Scholar 

  3. 3.

    Balaram SK, Tyrie L, Sherrid MV, Afthinos J, Hillel Z, Winson G, et al. Resection-plication-release for hypertrophic cardiomyopathy: clinical and echocardiographic follow-up. Ann Thorac Surg. 2008;86(5):1539–44.

    Article  Google Scholar 

  4. 4.

    Obadia JF, Basillais N, Armoiry X, Grinberg D, Dondas A, Barthelet M, et al. Hypertrophic cardiomyopathy: the edge-to-edge secures the correction of the systolic anterior motion. Eur J Cardiothorac Surg. 2017;51(4):638–43. PMID: 28007871 DOI. https://doi.org/10.1093/ejcts/ezw385.

    Article  PubMed  Google Scholar 

  5. 5.

    Collis R, Watkinson O, Pantazis A, Tome-Esteban M, Elliott PM, McGregor CGA. Early and medium-term outcomes of Alfieri mitral valve repair in the management of systolic anterior motion during septal myectomy. J Card Surg. 2017;32:686–90.

    Article  Google Scholar 

  6. 6.

    Sorajja P, Pedersen WA, Bae R, Lesser JR, Jay D, Lin D, et al. First experience with percutaneous mitral valve plication as primary therapy for symptomatic obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol. 2016;67:2811–8.

    Article  Google Scholar 

  7. 7.

    Ferrazzi P, Spirito P, Iacovoni A, Calabrese A, Migliorati K, Simon C, et al. Transaortic Chordal cutting: mitral valve repair for obstructive hypertrophic cardiomyopathy with mild Septal hypertrophy. J Am Coll Cardiol. 2015;66(15):1687–96.

    Article  Google Scholar 

Download references

Acknowledgements

Not applicable.

Funding

None.

Author information

Affiliations

Authors

Contributions

HN performed data collection and wrote the manuscript. AY supported the writing of the manuscript. CT and AI participated in the design of the study. JH and AT performed data collection. The author(s) read and approved the final manuscript.

Corresponding author

Correspondence to Hiroyuki Nakajima.

Ethics declarations

Ethics approval and consent to participate

All authors read and approved the final manuscript.

Approval of the Institutional Review Board of Saitama Medical University International Medical Center was waived.

Consent for publication

The patient provided informed consent for the publication of images.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Nakajima, H., Tokunaga, C., Hayashi, J. et al. Trapezoidal resection of an elongated anterior mitral leaflet and Alfieri stitch in hypertrophic cardiomyopathy. J Cardiothorac Surg 15, 311 (2020). https://doi.org/10.1186/s13019-020-01361-2

Download citation

Keywords

  • Hypertrophic obstructive cardiomyopathy
  • Mitral valve repair
  • Systolic anterior motion
  • Septal hypertrophy
  • Myectomy