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Comparison of flexible, open with semi-rigid, closed annuloplasty-rings for mitral valve repair



Mitral regurgitation is a frequent valvular disease, with an increasing prevalence. We analysed the long-term outcomes of mitral valve repair procedures conducted over the last 10 years in our clinic using almost exclusively two different annuloplasty ring types.


A single-centre, retrospective analysis of mitral valve surgeries conducted between January 2005 and December 2015 for patients undergoing first-line mitral valve repair with either open (Cosgrove) or closed (CE Physio / Physio II) annuloplasty (OA or CA, respectively) rings.


In total, 1120 patient documentations were available of which 528 underwent OA and 592 patients CA. The median age of patients was 64.0 years and 41.1% were female. The majority of these patients underwent the procedure because of degenerative valve disease. Rates of successful repair were about 90%, 72 h procedural mortality was 0.6% and the rate of re-intervention was 0.6% within the first 30 days. Functional (mitral regurgitation, left ventricular ejection fraction, left ventricular end-diastolic and systolic diameter and New York Heart Association class) as well as hard outcomes were comparable. 77.7 and 74.4% of patients were alive at the 10-year follow-up in the OA and CA groups, respectively. Upon multivariable adjustment, the hazard ratio was 0.926 (95% CI: 0.642–1.3135; p = 0.681).


The functional outcome and survival rates up to 10 years after mitral valve repair were comparable using open and closed annuloplasty rings. Whether this means these rings are interchangeable or a carefully selection of the best-for-the-patient devices will be subject of future investigations.

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Primary mitral regurgitation (MR) is the result of pathology affecting at least one component of the mitral valve apparatus and is usually the consequence of degenerative disease. Surgical intervention is associated with high repair rates and low operative morbidity and mortality [1]. Current international guidelines all advise mitral valve repair (MVR) for symptomatic patients with severe MR. [2, 3]

MR occurs because the two leaflets normally involved in sealing the mitral valve to retrograde flow may not coapt properly. MVR, therefore, comprises restoration of leaflet coaptation and the implantation of standardised annuloplasty rings [4, 5]. Annuloplasty has been shown to improve valve repair durability and stabilise the entire posterior mitral annulus [6, 7]. Although various annuloplasty devices are available including flexible vs. semi-rigid vs. rigid, incomplete vs. complete, planar vs. saddle-shaped and adjustable vs. non-adjustable, there is a lack of sufficiently powered data on the relative merits of each ring design [4, 5, 8, 9].

It was for this reason that we retrospectively gathered the patient and procedural characteristics of patients undergoing mitral valve repair in our clinic. As we almost exclusively use only two different ring types, we focused our analysis on the flexible, C-shaped open Cosgrove Edwards and the semi-rigid closed Carpentier-Edwards Physio / Physio II annuloplasty rings. The aim of this analysis was to compare the long-term outcomes.

Patients and methods

This study is a single-centre, retrospective analysis of mitral valve surgeries performed between January 2005 and December 2015. The study was approved by the site’s ethical committee and complied with the Declaration of Helsinki. Written, informed consent was not required due to the use of anonymised data already collected as part of routine practice.

Patient population

Patients undergoing mitral valve repair were included. Patients had to undergo annuloplasty ring implantation using either the flexible, C-shaped open Cosgrove Edwards flexible band (termed open annuloplasty or OA group) or the semi-rigid closed Carpentier-Edwards Physio / Physio II device (termed closed annuloplasty or CA group). Both devices (OA vs. CA) were used by all surgeons involved depending on the clinical situation. While there is a potential preference of either device type by surgeon, the degree of which was not documented. Potential concomitant procedures were tricuspid valve reconstruction, ablation of AF, left atrial appendage closure and ASD or PFO closure. Patients undergoing first-line mitral valve replacement, patients receiving other ring types and those undergoing concomitant coronary artery bypass graft or aortic valve surgery were excluded. Follow-up data concerning complications and echocardiographic parameters were collected at the patient’s last FU visit.

Endpoints of interest

We defined the following endpoints of interest for our analysis: 1) Survival, 2) freedom from reoperation, 3) the degree of postoperative MR, 4) the postoperative functional status based on the NYHA class, 5) the postoperative left ventricular ejection fraction (LVEF), and 6) the postoperative left ventricular enddiastolic diameter (LVEDD) / left ventricular endsystolic diameter (LVESD).


Data were analysed using descriptive statistics, with categorical variables presented as absolute values and frequencies (%) and the continuous variables presented as the median and interquartile range (IQR). Comparisons between the OA and CA groups were carried out using Mann-Whitney U-test for continuous variables and a Fisher’s exact or Chi-square test for categorical variables. Odds ratios (OR) were calculated by logistic regression and adjusted for the key baseline variables age, pulmonary hypertension, prior aortic valve replacement (AVR), LVEDD, LVESD, left/right atrium (mm), chordae elongation and logistic EuroSCORE. Survival analysis data was presented as Kaplan-Meier curves. In addition, hazard ratios (HR) were calculated by COX-regression and again adjusted for differences in the key baseline variables named above. In all multivariable analyses, only data of patients with available values for all variables taken into account for adjustment were included.

A two-tailed p-value of < 0.05 was considered statistically significant. All statistical tests were performed using IBM SPSS Statistics software version 24.0 (IBM Corporation, Armonk, NY, USA).


A total of 1357 patients were documented. Patients undergoing direct MVR (n = 201) and those receiving other annuloplasty rings than the Cosgrove-Edwards or the Carpentier-Edwards Physio/Physio II (n = 36) as part of their MVR were excluded. Of the remaining 1120 patients 528 were assigned to the OA group and 592 patients to the CA group (Fig. 1).

Fig. 1

Flow chart outlining study patient cohorts. Legend: none

Patient characteristics

Patients had a median age of 64.0 years and 41.1% were female (Table 1). Hypertension was a frequent risk factor (53.1%); diabetes (7.1%) and COPD (11.1%) were frequent comorbid conditions. Disease conditions associated with a causal relationship to mitral valve (MV) disease were pulmonary hypertension (10.0% of patients) and AF (29.7%). Overall, 73.6% of patient had NYHA III/IV defined symptoms. The median logistic EuroSCORE was 3.3%.

Table 1 Patient characteristics

More patients in the OA group had prior aortic valve replacement (2.5 vs. 0.8%; p = 0.032) and a higher logistic EuroSCORE I (3.5 vs. 3.0%; p = 0.032) (Table 1).

Mitral valve surgery

The majority of patients in both groups underwent mitral valve repair because of a degenerated valve (92.6 in the OA vs. 93.5% in the CA groups; p = 0.523) (Table 2). There were echocardiographic differences between groups including a lower left (median 52.0 vs. 55.0 mm; p = 0.002), right atrial diameter (45.0 vs. 47.0 mm; p = 0.016) and a reduced mitral opening (median 3.7 vs. 4.1 mm; p = 0.021) in the OA group.

Table 2 MV pathology and echocardiographic parameters and procedural details

Fewer patients receiving OA had minimal invasive valve surgery (p < 0.001) and AML reconstruction (p < 0.001) and the inserted annuloplasty rings generally had a smaller size (Table 2). PML quadrangular resection was more common with OA (23.3% vs. 12.3%; p < 0.001), while neo-chordae AML were more common with CA (15.2% vs. 8.9%; p = 0.001) as was cleft plicature (28.2% vs. 14.2%; p < 0.001). Concomitant procedures (including atrial fibrillation (AF) cryoablation, left atrial appendage (LAA) closure and tricuspid valve repair) were comparable in both groups. The number of patients requiring patent foramen ovale (PFO) closures, however, was higher in the OA group. The cardio-pulmonary bypass time as well as the overall procedure time was shorter in the OA group.

There was a high rate of successful repair reaching 88.4% in the OA and 90.5% in the CA group (p = 0.253). Only 8 patients undergoing minimal invasive surgery in either group were converted to median sternotomy (2.2%). Pleural effusion was 1.7% in the OA group and 2.7% in the CA group multivariable adjusted OR 0.34 (95%CI: 0.12–0.99).

Functional outcomes

The median MV gradient in patients receiving an OA was 4.0 at both the baseline and follow-up (FU) visit, whereas it was reduced from 4.0 to 3.1 at FU in patients with CA. Thus, the median gradient was significantly different between both groups at the mean 6.1 year FU (p = 0.048) (Fig. 2a) which was a potential result of greater ring sizes in the CA group (p < 0.001). The proportion of patients with II° or III°/IV° grade mitral insufficiency was strongly reduced after the intervention and at 6.1 years with no difference between the OA and CA patient groups (Fig. 2b). Postoperative Systolic Anterior Motion was observed in 52 out of 1120 patients with no statistically significant difference between groups (OA 4.4% vs. CA 4.9%; p = 0.667). There was, however, a noteworthy trend with higher rates of I° degree mitral insufficiency at 6.1 years FU compared with the immediate postoperative period.

Fig. 2

Mitral valve gradient and competency. Legend: none

The LVEF dropped from a median baseline value of 60% (e.g. pre-intervention) to a median LVEF of 55% post-procedurally. There were no differences in the LVEF at baseline (p = 0.660) or after the intervention (p = 0.316) between groups. LVEF recovered later on (5.8 years) back to the baseline value of 60% which was identical in both groups (p = 0.906) (Fig. 3a). LVEDD was 55 mm in the OA group and 56 mm in the CA group at baseline and 50 mm in both groups at the follow-up. While their difference at baseline was statistically significant (p = 0.003), it was not at the follow-up (Fig. 3b). LVESD was 35 mm and 36 mm, respectively at baseline (p = 0.001) and 37 mm at the follow-up in either group (p = 0.559).

Fig. 3

Left Ventricular Dimension and Function. Legend: none

In agreement with the decrease in mitral valve insufficiency at a preserved LVEF, there was a considerable improvement of symptoms observed with the majority of patients being NYHA I or II at 6.3 years (Fig. 4) with no difference between groups (p = 0.133).

Fig. 4

NYHA class. Legend: none

Hard outcomes

The rates of re-intervention following the immediate post-procedural phase and up to 30 days was 0.6% in the OA and 0.5% in the CA group (adjusted OR 0.97; 95%CI 0.17 to 5.47).

Immediate within 72 h procedural mortality affected 7 out of 1120 patients (0.6%). Outcomes at 30 days showed comparable rates for all-cause death, stroke, acute renal failure, MI and pacemaker between groups (Table 3). An initial significant difference in the rate of non-CV death disappeared upon adjustment for differences in baseline characteristics (adjusted OR 5.00; 95%CI 0.52–48.28). Long-term mortality was comparable between patients in the OA and CA groups, with an estimated 10-year survival of 77.7 and 74.4% for patients, respectively (log rank p = 0.300; adj. HR 0.926 (95%CI: 0.642–1.3135; p = 0.681) (Fig. 5).

Table 3 Procedure-related complications and 30-day outcomes
Fig. 5

Kaplan-Meier curve for the long-term survival after MVR. Legend: HR calculated by COX regression was 1.171 (95%CI 0.868–1.580; p = 0.300). After adjustment for age, pulmonary hypertension, prior AVR, LVEDD, LVESD, left/right atrium (mm), chordae elongation and log EuroSCORE the HR was 0.926 (95%CI 0.642–1.3135 p = 0.681) in favour of closed annuloplasty ring. In the multivariate Cox analysis only data of patients with available values for all variables taken into account for adjustment were included (n = 820)


In our dataset of 1156 MVR procedures, we almost exclusively used the open Cosgrove-Edwards and the closed Carpentier-Edwards Physio/Physio II in patients with degenerative valve disease. Rates of successful repair were about 90%, 72 h procedural mortality was 0.6% and the rate of re-intervention was 0.6% within the first 30 days. Functional as well as hard outcomes with both ring types were largely comparable, with a slightly higher MV gradient seen with time in the CA group.

To the best of our knowledge, our dataset is the largest study with the longest follow-up so far comparing the use of open and closed annuloplasty rings for the treatment of MR. The majority of the patients experienced substantial improvement of their mitral insufficiency and symptom status. Interestingly, at 6.1 years, there was a slight worsening in the degree of mitral valve insufficiency with an increase in I° MR. It is reassuring though, that III° and IV° degree MR was not observed during our long-term follow-up giving confidence that the procedure achieved its clinical goals.

In an attempt to quantify potential differences between different annuloplasty rings, Khamooshian et al. performed a secondary data analysis [10]. They clustered the large number of more than 37 available rings into 3 groups of flexible, semi-rigid and rigid rings and focused on patients with either degenerative etiology or those patients with ischemic / dilated cardiomyopathy. They found that irrespective of the ring used, the LVEF remained unchanged after the intervention (just as in our analysis), the LVESD decreased with the use of all ring types, and LVEDD only decreased with the use of flexible and rigid rings, while there was no decrease associated with semi-rigid rings. We observed a decrease in both OA (with the flexible ring) and CA groups (with the semi-rigid ring), with no nominal difference between groups. The drop is unlike as in the Khamooshian analysis. LVESD was essentially unchanged at the follow-up.

A Pubmed search of the available literature over the last 10 years in June 2019, the keywords “annuloplasty, mitral, ring, comparison” resulted in a total of 41 references, of which seven actually presented a comparison of at least two different rings (1 animal model [11], 2 restricted to ischemic etiology [12,13,14] and 4 which did not specify the etiology [15, 16] as well as one computer-based modelling study [17]). The majority of these did not report on long-term functional and survival benefits, but focused on short-term hemodynamic results. Nishi [15] et al. found, that using the Cosgrove (n = 10), Sorin-Memo 3D (n = 17) and CE Physio II (n = 7) implantation rings, all controlled mitral regurgitation well, the Cosgrove more than the Sorin-Memo more than the CE Physio II had a dynamic diastolic to systolic change in mitral annular diameter during the cardiac cycle. Tsuneto [16] et al. reported from 31 patients, that the Cosgrove was found to be more flexible, while the Sorin-Memo ring maintained the elliptical shape more efficiently. Bouchez [18] et al. reported in a comparison of the CE Physio II (n = 17) with the Memo 3D (n = 16) that the mitral annulus dynamics after annuloplasty with the Physio II and Memo 3D rings demonstrated a better systolic 3D restoration of the saddle shape with the Physio II ring, whereas the saddle-shaped geometry improved significantly with the Memo 3D ring, as a dynamic phenomenon. The Memo 3D ring also showed increased anteroposterior annular mobility and folding dynamics throughout the cardiac cycle.

Silberman [13] et al. was the only to report on longer-term clinical outcomes in his report of 169 patients with ischemic MR. The symptom status (NYHA) was class III / IV in 33% with the flexible ring and 14% with the rigid ring (p = 0.03, MR grade was 1.15 and 0.7 (p = 0.006), respectively. There was no difference in LV function or dimensions. At follow-up, 29 patients (34%) in the flexible group had residual MR of moderate degree or greater compared with 6 (15%) in the rigid group (p = 0.03). Late mortality was observed in 32 out of 117 patients, which affected exclusively the flexible group (FU 58 months in the flexible and 14 months in the rigid group). Although these data on ischemic MR are reported on the same outcome, their quantity is hard to compare to our results as our database was exclusively built on degenerative mitral disease.


There were several limitations to this study. Firstly, due to its retrospective nature, data for certain fields may have been missing. Secondly, there were baseline differences between OA and CA groups, representing a possible source of bias. Thirdly, in the multivariate analyses, only data of patients with available values for all variables were taken into account for adjustment purposes (no imputation). Finally, major complications and echocardiography data were collected at the patient’s last FU visit – this data was not available for some patients as they only recently received their implant and it also excluded data for those patients lost to FU.


In summary, our study showed that the use of OA and CA rings for the treatment of patients undergoing mitral valve repair were comparable, with both types of rings reducing mitral insufficiency and improving NYHA scores immediately after treatment, as well as at 30-days and ~ 6 years after treatment. Whether this means these rings are interchangeable or a carefully selection of the best-for-the-patient devices will be subject of future investigations.

Availability of data and materials

Data are available from the corresponding author upon reasonable request.



Atrial fibrillation


Anterior mitral valve leaflet


Atrial septal defect




Closed annulopasty


Coronary artery bypass graft


Coronary artery disease


Canadian Cardiovascular Society


Chronic obstructive pulmonary disease


Cardiopulmonary bypass


Conventional sternotomy




Hazard Ratio


Intensive care unit


Interquartile range


Left atrial appendage


Left ventricular end-diastolic pressure


Left ventricular ejection fraction


Left ventricular end-systolic pressure


Minimally invasive mitral valve surgery


Mitral valve


Mitral valve insufficiency


Mitral valve surgery


New York Heart Association


Open annulopasty


Odds Ratio


Peripheral artery disease


Proximal isovelocity surface area


Patent foramen ovale


Posterior mitral valve leaflet


Tricuspid valve repair


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Author information




AC, MW, SH, MS and MR performed the surgery and collected the data. AC, KB, MZ, OJL, and PB worked on the dataset, designed the analyses and developed the concept. AC and PB drafted the manuscript which was critically revised by MW, OJL, MZ, SH, KB, YHC, MS, and MR. All authors approved the final version of the manuscript and can be held accountable for the integrity of the work.

Corresponding author

Correspondence to Yeong-Hoon Choi.

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Ethics approval and consent to participate

The study was approved by the site’s ethical committee and complied with the Declaration of Helsinki and its amendments. Given the use of anonymised data already collected as part of routine diagnosis and treatment, written informed consent was not required.

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Not applicable.

Competing interests

Peter Bramlage received research funding from Edwards Lifesciences related and unrelated to the present work. The other authors have no conflict of interest to disclose.

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Cetinkaya, A., Waheed, M., Bramlage, K. et al. Comparison of flexible, open with semi-rigid, closed annuloplasty-rings for mitral valve repair. J Cardiothorac Surg 16, 35 (2021).

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  • Mitral valve repair
  • Mitral regurgitation
  • Annuloplasty
  • Open ring
  • Closed ring