Predictors of temporary epicardial pacing wires use after valve surgery

Starting 1960s, temporary epicardial pacing wires (PWs) were routinely placed in all cardiac operations for therapeutic as well as diagnostic purposes[1, 2]. They remain in place anywhere from 24 hours to several days postoperatively and are used to maintain heart rate and rhythm which are necessary to optimize haemodynamics[3] and to suppress both atrial and ventricular tachyarrhythmias[4]. The use of PWs is associated with increased resource utilization and infrequent, but life threatening complications including hemorrhage, cardiac tamponade, serious arrhythmias, and death. Also the retention of PWs after cardiac surgery is not necessarily safe and may cause serious complications[5–11].

The available data supports the use of PWs for selected cases after coronary artery bypass grafting (CABG) surgery[5, 6]. However, PWs are routinely inserted after valve and congenital heart surgeries promoted by historical evidence of increased need for temporary cardiac pacing (TCP) in such surgeries[12–14]. Recent limited publications suggest a trend towards selective use[15, 16]. Ferrari et al.[15] reported TCP in 17% of their valve surgery cases and Gupta et al.[16] in 30% of their congenital heart surgery cases.

The aim of this study was to determine the predictors of TCP in valve surgery with the potential to regulate PWs insertion at our center.

A total of 400 consecutive patients underwent valve surgery with ages ranging from 18 to 80 years with mean age (standard deviation- SD) of 51.81 (13.71) years. Group 1 consisted of 170 (42.5%) patients with mean age (SD) of 44.25 (12.85) years. No patient in group1 required pacing by any means nor suffered any complication attributed to avoidance of PWs. Group 2 consisted of 230 (57.5%) patients with mean age (SD) of 57.39 (11.49) years. Table 1 shows the characteristics of both groups with p-values. Among patients in group 2, only 55 (23.9%) needed TCP (mean age (SD) = 62.27 (10.87) years) and were compared with the remaining 175 (76.1%) patients (mean age (SD) = 55.86 (11.27) years) who did not need TCP. 12-lead ECG was used to diagnose conduction disturbances. The primary reasons for pacing included AVB of any degree in 25 (45.5%) patients, nodal or junctional rhythms in 8 (14.6%) patients, low cardiac output in 13 (23.6%) patients, sinus bradycardia in 5 (9.1%) patients, and asystole in 4 (7.2%) patients. In no case were PWs used for diagnostic purposes, rapid atrial pacing, or left ventricular pacing. PWs were left in place for a minimum of 3 days. The mean (SD) duration of pacing was 53.12 (31.81) hours; the median was 12.5 hours. Only 5 (9.1%) of the 55 patients who needed TCP, had implantation of permanent pacemaker, accounting for 1.25% of the cohort analyzed. The average time from surgery to implantation of permanent pacemaker was 65.33 hours.

Historically, PWs have been routinely used after cardiac operations to optimize cardiac function and to suppress both atrial and ventricular tachyarrhythmias[4]. However, their use is not innocuous and associated with infrequent but lethal complications. Insertion can prolong the operative time and increase the risk of bleeding. Their extended use can result in failure of sensing or capturing[17]. During removal, patients are at risk of ventricular arrhythmias[18] and to a lesser extent bleeding due to injury of nearby structures[19–21]. Also retention of PWs may be complicated by deep seated infections or migration to different structures in the chest[7–9, 22, 23].

During the last decade, routine insertion of PWs in CABG surgery, being on-pump or a beating heart, has been well studied and many centers turned to limit their use[5, 6, 24]. We already comply with these policies. In valvular and pediatric surgeries there is a historical evidence of routine use of PWs due to the increased risk of AVB[12]. However, these recommendations are decades old and may not reflect modern surgical techniques and practice. Recent few reports studied the rate and the predictors of TCP after valvular and pediatric cardiac surgeries[15, 16, 25]. At our center, to avoid the above mentioned complications and in accordance with the published literature, and it is upon surgeon’s discretion to safely select patients, we limited the insertion of PWs in valve surgery (usually based on; young age with minimal comorbidities, uncomplicated single valve surgery, not involving extensive decalcification, and after separation from CPB in sinus rhythm, and hemodynamically stable on minimal support, including recently, patients in sinus bradycardia who responds to minimal doses of beta-adrenergic drugs) (Table 1).

The need for TCP was mainly based on the presence of a mechanical injury to the conduction system caused by operative procedures in close physical proximity to the atrioventricular node or the His bundle, or an ischemic injury to the conduction system resulting during cardioplegic arrest, especially if associated with extensive coronary artery disease. Both mechanisms may evoke preexisting conduction defects or generate new ones.

In our study, only 23.9% of valve surgery patients with PWs insertion needed TCP which led us to reevaluate the use of PWs and to attempt to identify a subpopulation of valve patients for whom PWs are appropriate.

In the current series, patients who had PWs inserted were almost 10 years older than those who did not, and those more than 60 years old were, by both univariate and multivariate analysis, more likely to be paced.

Gender was not a predictor of TCP. This is consistent with other peer reviews[15, 26].

Data in the literature regarding the significance of chronic comorbidities such as chronic renal failure, chronic obstructive pulmonary disease, diabetes mellitus and preoperative arrhythmias as predictors of postoperative pacing are conflicting[14, 15, 27]. In our study none of the above mentioned comorbidities were significantly associated with the need for TCP in the multivariate analysis.

Advanced NYHA class was a predictor of TCP in both univariate and multivariate analysis. Pacing was used in patients with advanced NYHA class to improve cardiac output after separation from CPB to achieve hemodynamic stability. Also, most of them had severe left ventricular dysfunction with increased risk of developing various conduction disturbances[28]. This finding was supported by Gordon et al.[29]. On the contrary, advanced NYHA status was not a predictor of TCP by Ferrari et al.[15].

Increased PAP was an independent predictor of TCP by both univariate and multivariate analysis. Limongelli, et al.[30] reported pulmonary hypertension a risk factor for postoperative AVB following aortic valve surgery, as it acts on the right ventricular dimensions and shape, and interventricular septal thickness imposing progressive mechanical stretch that could affect the conduction system by altering the electrophysiological properties of its fibers.

Preoperative use of digoxin and beta-blockers are postulated as predictors of postoperative conduction disturbance[14, 31], especially of those with the block nature. In a recent study on patients after mitral valve surgery by Berdjas et al.[14], both digoxin and beta blockers, were found to significantly lower the risk of conduction disturbances. In our study, only digoxin was a predictor of TCP. Digoxin’s primary mechanism of action is to increase the force of myocardial contractility in failing hearts by increasing the intracellular calcium concentration. However, its vagomimetic effect decreases sinoatrial and atrioventricular conduction and prolongs atrioventricular node refractory period, thus increasing the need for TCP[32]. Also digoxin has, even at therapeutic levels, an arrhythmogenic effect on ischemic hearts[33], which may include periods of prolonged crossclamping time.

Type of surgical procedure was a determinant of TCP. Patients who had multiple valve surgery and/or debridement of heavy annular calcification at the atrioventricular sinus area (the posterior commissure of the anterior mitral leaflet, the commissure between right- and noncoronary cusps of the aortic valve, and the septal leaflet of the tricuspid valve) were at an increased risk of physical injury to the atrioventricular node and conduction system and were significantly more likely to need TCP after separation from CPB. Although the need for pacing in combined valve and CABG surgery was more than in isolated single valve surgery, this difference did not reach statistical significance. This might be due to small sample size of this subgroup. In such patients it may be difficult to assure adequate and uniform delivery of the cardioplegic solution to protect the myocardium leading to new or further exacerbating existing conduction disturbances. These results coincide with other peer reviews[29, 34].

Aortic crossclamp time more than 60 minutes, by both univariate and multivariate analysis, was a predictor of TCP. This is consistent with other peer reviews[35]. The occurrence of ischemic injury to the conduction system and the development of myocardial edema following prolonged periods of crossclamping might explain these findings.

In the interpretation of the study findings, we need to consider that this study is a retrospective analysis with a relatively limited number of patients done over a long time; however patients were followed prospectively during their hospitalization. Although a team of different surgeons performed the operations with different threshold for postoperative PWs insertion and pacing, all the patients were treated at a single center, and the operative methods remained substantially unchanged during the study.

Although limited by sample size, the present results suggest that routine use of PWs after valve surgery is necessary for high risk patients. Predictive factors of TCP after valve surgery were increased age, NYHA class (III-IV), PAP ≥ 50 mmHg, digoxin use, complex surgical procedures (i.e. multiple valve surgery), heavy annular calcification, and crossclamp time ≥ 60 min. Better patients selection, in addition to optimizing the medical condition through aggressive treatment of heart failure and pulmonary hypertension, shortening the cross clamping and CPB times, and careful debridement of calcified valve annulus, may lower the need for postoperative pacing in our practice. Prospective randomized well controlled studies on a larger number of patients, including quantitative assessment of valve annular calcium load and distribution, are necessary to draw solid conclusions on safely selected patients who do not require postoperative PWs insertion.